Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"transcription factor regulation"”.
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Inferring the properties of transcription factor regulation
The regulatory targets of transcription factors are costly to directly detect using existing technologies. Many computational models have thus been developed to infer the genes targeted by TFs using gene expression profiles, position weight matrices modeling TF protein binding, histone …
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Transcription factor regulation of T helper subset function
… subsets of T helper cells is governed by transcription factors. Previous work demonstrated a requirement for the transcription factor PU.1 in the development of IL-9-secreting Th9 cells. Work in this dissertation demonstrates that the Th9 subset is not stable in vitro, and that PU.1 …
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TET1 AND TRANSCRIPTION FACTOR REGULATION OF LINEAGE SPECIFICATION DURING MOUSE GASTRULATION AND EARLY ORGANOGENESIS
… arise during this period are defined by distinct transcriptional programs that depend on specific remodelling of the epigenome and Transcription Factor (TF) networks. In this thesis, I focus on the cell type-specific TFs and Ten-eleven Translocation methylcytosine dioxygenase 1 (TET1), an …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… identified STAT1 as a mediator of iCAF-induced transcriptional reprogramming. STAT1 was found to associate with accessible chromatin regions and to co-occupy a subset of sites with FOXA1/FOXA2, promoting expression of interferon (IFN)-α/γ response genes. Inhibition of IFN-β was sufficient to …
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Biophysical mechanisms of intrinsic protein disorder: lessons from a protein backbone model
… ensemble of structures. Proteins involved in the regulation of critical cellular functions rely on IDRs to carry out their functions. IDRs have been implicated in a number of diseases for which there are currently no treatments. To successfully target drugs to IDRs, a quantitative description of …