Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"transcription factor genes"”.
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Identification of transcription factor genes in plants
… this control is to regulate the initiation of transcription. This step requires the assembly of several components, i.e., a basal/general machinery common to all expressed genes, and a specific/regulatory machinery, which differs among genes and is the responsible for proper gene expression in …
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The identification of potential cis- and trans-acting factors in the regulation of DARK INDUCIBLE 3 (DIN3) expression during darkness and chilling in Arabidopsis thaliana
… 3 (DIN3), specifically the cis- and transacting factors. To achieve these aims, the investigative approach centred on gene expression analysis of linker-scan mutation analysis of 50 base-pairs (bp) of the minimal functional promoter of DIN3. To investigate the contribution made by transacting …
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Identification and characterization of conserved regulatory elements by comparative genomics
… identify conserved noncoding elements (CNEs) in genes expressing in the human forebrain, and to characterize selected CNEs in transgenic mice. To this end, genomic sequences for 50 human genes were aligned with their orthologous sequences in mouse and fugu. 206 CNEs associated with 29 genes were …
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Nitrogen signalling in Arabidopsis thaliana
… in agriculture. To identify nitrogen-regulated transcription factor genes in Arabidopsis that may control N-use efficiency we developed a unique resource for qRT-PCR measurements on all Arabidpsis transcription factor genes. Using closely spaced, gene-specific primer pairs and SYBR® Green to …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… leukemia. Wild-type AF9 is a member of the pTEFb transcription elongation complex, and interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are retained in the oncogenic MLL-AF9 fusion protein, and may be required for leukemic …
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Developmental Regulation of Oil Deposition in Arabidopsis Seeds
The Arabidopsis transcriptional factors LEAFY COTYLEDON1 (LEC1), LEAFY COTYLEDON2 (LEC2), FUSCA3 (FUS3), ABSCISIC ACID INSENSITIVE3 (ABI3), and ABSCISIC ACID INSENSITIVES (ABI5) are known to regulate multiple aspects of seed development. In an attempt to understand the developmental control of …
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Transcriptional regulators in stem cell biology
… enable cancer stem cells to promote tumorigenesis. Transcriptional modulation, enacted by proteins including epigenetic regulators and transcription factors, determines cell fate. However, the functions of transcriptional regulators of stemness may differ in normal and transformed cells. In …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
Tbx4 and Tbx5 are two closely related genes that belong to the T-box family of transcription factor genes. Loss of Tbx4 results in absence of chorio-allantoic fusion and a failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. Using a candidate …
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Branching out: how a planarian neoblast generates cellular diversity
… and post-mitotic progenitor types, and the genes that define them. Because neoblasts subtypes are often specified by their unique expression of Fate Specific Transcription Factors (FSTFs), we computationally identify planarian transcription factor genes and characterize neoblasts and …
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Regulatory dynamics of the Tbx18 locus in mouse urogenital development
… to these structures are shared. The T-box transcription factor TBX18 is expressed in these mesenchymal cells and beginning at mid-gestation, Tbx18 expressing cells coalesce on the ureter and urogenital sinus epithelia, then differentiate into the smooth muscle layer. The loss of Tbx18 …
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Identification of Drosophila heart-specific Cis-Regulatory Modules under Hox control
Cardiac morphogenesis is a complex process governed by evolutionarily conserved transcription factors and signaling molecules. The Drosophila cardiac tube is linear, made of 52 pairs of cardiomyocytes (CMs), which express specific transcription factor genes that have human homologues implicated in …
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Characterization of Bacterial Transcriptional Regulatory Networks through Genome-Wide in vitro Run-Off Transcription RNA-Seq (ROSE)
The current methods for characterizing transcriptional regulatory networks are limited to in vivo conditions, providing a snapshot of multiple regulatory interactions simultaneously. To complement these approaches, a new method called ROSE (Run-Off transcription/RNA-sequencing) has been developed …
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Global transcriptional, post-transcriptional, and translational regulation during soybean seed and seedling development
… in a highly organized fashion to ensure specific genes are expressed at the appropriate levels during soybean seed and seedling developmental stages. To define the developmental shifts in gene expression and begin to understand the gene regulatory networks, high-throughput RNA sequencing (RNA-Seq) …
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DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION
… have allowed for identification of several transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary hormone deficiency …