Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"transcription factor dynamics"”.
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Investigating transcription factor dynamics and chromatin environment during Notch response
… forms an activation complex with the DNA-binding transcription factor CSL (Su(H) in Drosophila) and the co-activator Mastermind. Binding of the activation complex promotes target gene expression. An added layer of complexity to this pathway is that Su(H) can also form a repressor complex with the …
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THE ROLE OF TRANSCRIPTION FACTOR DYNAMICS IN GENE EXPRESSION: DOES TIME MATTER?
… and silencing of genes in a process called transcription. Understanding transcriptional regulation is of utmost importance to reveal mechanisms behind cell homeostasis and pathologies. The transcription machinery needs to be perfectly tuned in space and time to control the expression of …
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Transcription Factor Dynamics Investigated through Single-Molecule Imaging, High-Throughput Sequencing, and Neural Networks
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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RNA-level controllers for programmable gene expression in mammalian cells
… of this gene from interference by the endogenous transcriptional unit. We incorporate this strategy into genetic controllers and leverage live cell imaging to develop a versatile strategy for probing the role of transcription factor dynamics on and enforcing the levels of transcription factors in …
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The NuRD complex regulates chromatin dynamics driving exit from naïve pluripotency
… ESCs to dissect its role in the regulation of transcription factor (TF) binding dynamics, chromatin accessibility, genome organisation and ultimately gene expression in naive pluripotency through to lineage specification. Single-molecule tracking of pluripotency-associated TFs in live mouse …