Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"transcription factor activation"”.
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High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling
… In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant organs. These spatially and temporally diverse cues are integrated by signal transduction cascades to modulate the …
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The role of reactive oxygen species as mediators of respiratory syncytial virus induced pulmonary inflammation
… signaling molecules involved in STAT and IRF transcription factor activation and the IKK-epsilon pathway, two activated pathways involved in the regulation of pro-inflammatory gene expression. We showed that RSV induced oxidative stress in vivo and that antioxidant therapy with butylated …
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Regulatory factors of milk fat synthesis in dairy cows
… investigate the milk fat synthesis regulation by transcription factors. In the first study, bovine mammary epithelial (MAC-T) cells were treated with sterol regulatory element binding protein-1 (SREBP-1) specific siRNA. The mRNA and protein expression of SREBP-1 were decreased by more than 90% by …
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Probing the Mechanisms Underlying the Regulatory Effects of Cactin in Innate Immune Signalling Pathways
… which are characteristic of invading pathogens. Activation of TLRs initiates signalling cascades resulting in the activation of transcription factors such as NF-κB and members of the interferon regulatory factor (IRF) family which regulate gene expression and mediate an immune response to the …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… procedure consisting of basic fibroblast growth factor (bFGF), heparin and laminin (FHL), which directs human fetal neural stem cells (hNSCs) to differentiate into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the …
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Understanding cell decision-making using near-infrared quantum dots: One cell, one molecule at a time
Cell receives input signals such growth factors from the environment and decides an appropriate output such as migration, division, differentiation, and apoptosis. This decision making process is tightly controlled, and when misregulated leads to pathogenesis such as cancer, immune disease, and …
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Investigating TLR-4 signalling in response to protein ligands
… a signalling cascade which results in nuclear factor (NF)-κB transcription factor activation and production of pro-inflammatory effector molecules such as the cytokine Tumour Necrosis Factor (TNF)-α. Upon activation TLR-4 is also endocytosed where it interacts with a second set of adaptor …
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The Roles of a Conserved MAP Kinase Pathway in the Regulation of Development and Secondary Metabolism in Aspergillus Species
… signifying reduced MAP kinase signalling and transcription factor activation. Deletion of any of the five members of the complex results in reductions in asexual sporulation, as well as complete inhibition of sexual cleistothecia formation and dramatic decreases in the expression levels of …