Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"transcription factor EB"”.
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MODULATING TFEB ACTIVITY IN THE BIRT-HOGG-DUBE' SYNDROME BY TARGETING THE VACUOLAR ATPASE
The transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy, and its activity is primarily controlled by the kinase complex mTORC1. In the Birt-Hogg-Dubé (BHD) syndrome, a genetic disease caused by germline mutations in FLCN gene, TFEB was found to be …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
… triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating copper clearance and reducing toxicity. Lysosomal Ca2+ release through transient receptor potential mucolipin 1 (TRPML1) activates calcineurin, which dephosphorylates TFEB, promoting its nuclear …
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Inhibition of TFEB activation promotes Coxiella burnetii growth
… Lysosomal biogenesis is regulated by the master transcription factor EB (TFEB). Its ability to act as a transcription factor depends on its subcellular localization, which relies on its phosphorylation state. TFEB, when phosphorylated is cytosolic and inactive, whereas dephosphorylated TFEB …
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The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… stress is as yet unknown. Recently, the transcription factor EB (TFEB) has emerged as a key regulator of lysosomal genes in multiple tissues, especially in response to external stress. Here, we set out to test the hypothesis that TFEB-dependent control of lysosomal biogenesis is required …
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FoxO1 in the regulation of adipocyte autophagy and biology
… biology. Given that metabolic stress activates transcription factor FoxO1 in obesity, my dissertation project is designed to depict the role of FoxO1 in adipocyte autophagy and biology. We found that FoxO1 upregulation was concomitant with elevation of autophagy activity during adipogenesis. …
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Fluorescence lifetime imaging microscopy to study protein aggregation in the context of neurodegenerative diseases
… autophagy-lysosomal pathway, as modulated by transcription factor EB (TFEB). The latter is triggered by increased de-acidification of lysosomes, which also leads to a collapse in tubular endoplasmic reticulum (ER) and mitochondrial fission. Macroautophagy needed for degradation and clearance …
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Differential Autophagic Responses to Nano-Sized Materials
… primary particle diameters were found to induce transcriptional upregulation of the lysosome-autophagy system. Prolonged exposure to titanium dioxide nanoparticles, however, induced lysosomal membrane permeabilization, leading to blockage of autophagic flux and accumulation of autophagic …