Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"transcription elongation"”.
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Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes
… genes (PRG’s) is regulated at the step of transcription elongation. Shortly after transcription initiation, RNA Polymerase II (Pol II) pauses and it only enters into productive elongation after inducible transcription factors (TF’s) recruit the P-TEFb kinase to phosphorylate Pol II in …
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Chromatin Control of the Antiviral Response to Influenza
… as scaffolds for protein complexes controlling transcription or co-transcriptional processes, thus impacting gene expression. Histone tail modifications are regulated by multiple, often overlapping pathways in the cell, and as such, present an important regulatory "node" through which the cell …
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Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation
During transcription, cyclin-dependent kinases (CDKs) dynamically phosphorylate the C-terminal domain (CTD) of RNA Polymerase II (RNAPII) to recruit factors that coordinate transcription and mRNA biogenesis. Cdk12 phosphorylates Serine 2 (Ser2) of the RNAPII CTD, a modification associated with the …
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Genetic, Biochemical, and Electron Microscopic Analysis of Components Involved in Transcription Coupled mRNA Export
… SUB2 and the THO complex, which is involved in transcription elongation. These data contributed to the identification of a novel conserved complex called TREX (transcription/export), formed by the export factors Sub2 and Yra1, a previously unknown factor, Tex1, and the THO complex. Thus, the …
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Mechanism of Incorporation and Repair of Uracil At Highly Transcribed Genes In Saccharomyces Cerevisiae
… and mutagenesis are elevated by high levels of transcription. The correlation between transcription and genome instability is largely explained by the topological and structural changes in DNA and the associated physical obstacles generated by the transcription machinery. However, such …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
… dimers (CPDs) and bulky chemical adducts. Transcription coupled repair (TCR) is a subpathway of NER dedicated to rapid removal of lesions in the transcribed strand of actively transcribed genes. The TCR mechanism in bacteria has been relatively well elucidated. However, TCR in eukaryotic …
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Mechanism of Transcription Arrest By The Nun Protein of Bacteriophage HK022
Transcription elongation is universally subject to regulatory factors that alter the rate and processivity of gene expression (Roberts et al, 2008). Escherichia coli RNA polymerase (RNAP) and its auxiliary transcription factors have long been studied as a model for understanding regulation of …
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Genes with internal repeats require the THO complex for transcription
… that have long internal tandem repeats. FLO I transcription elongation in Tho- mutants is hindered in the region of the tandem repeats, resulting in a loss of function. Moreover, the repeats become genetically unstable in Tho- mutants. A FLO I gene without the tandem repeats is transcribed …
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DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION
… REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION MAJOR PROFESSOR: Dr. Blaine Bartholomew Chromatin remodelers are conserved from yeast to humans and are the gatekeepers of chromatin. They regulate transcription by occluding or exposing DNA regulatory elements globally. …
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Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
… suppression of both induced and basal HIV transcription in microglial cells (HC69) and monocytic cell lines (U1 and OM10.1). Pre-treatment of microglia with ZL0580 renders them more refractory to latent HIV reactivation, indicating epigenetic reprogramming effect of ZL0580 on HIV LTR in …
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Mechanisms of recruitment of the CTD phosphatase Rtr1 to RNA polymerase II
… state prior to forming a competent transcription initiation complex. However, during transcription, specific kinases and phosphatases act on the RNAPII CTD to regulate its phosphorylation state, which serves to recruit sequence-specific and general transcription factors at the …
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… chromatin structure remodelling and reprogrammed transcriptional profiles. Unbiased proteomic analysis revealed that ARID1A-depleted tumours exhibit a reduced reliance on the pioneer factor FOXA1, as evidenced by a marked collapse of the FOXA1 interactome. Conversely, these tumours transitioned to …
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Investigating the Double-Edged Sword of Rifampicin Resistance in Mycobacterium Tuberculosis
… of the RNA exit channel, potentially disrupting transcription elongation. As is true for many other bacteria, drug resistance in Mtb is often associated with a fitness cost in the absence of antibiotics, and Rif resistance is no exception. RifR Mtb is frequently less fit than RifS Mtb and …
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Defining the molecular basis for the β-catenin and CDC73 interaction
… of protein coding genes. To initiate gene transcription, Pol II is recruited to gene promoters by transcription factors. Gene specific transcription factors, including β-catenin, a component of the Wnt signaling pathway, are used to regulate gene expression in response to developmental or …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
Signal-induced transcriptional programs regulate critical biological processes through the precise spatio-temporal activation of inducible gene programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the …
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INVESTIGATION OF THE NOVEL ANTITERMINATION MECHANISM OF LOAP, A NUSG SPECIALIZED PARALOG
The transcription factor NusG plays an important role in the transcription elongation complex across all domains of life. During elongation, the NusG-NTD forms contacts to RNAP while the NusG-CTD dynamically interacts with other proteins, affecting processivity, transcription termination, and in …
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Epigenetic Regulation of Replication-Dependent Histone mRNA 3 End Processing
… (suppressor of Ty 5 homolog), NELF-E (negative elongation factor-E) und wahrscheinlich UBE2A (ubiquitin-conjugating enzyme E2A) reguliert werden. Hierbei handelt es sich ebenfalls um von CDK9 phosphorylierte und somit regulierte Transkriptionsfaktoren. Interessanterweise sind die CDK9-Aktivität …
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Investigating the interactions of G-quadruplexes with transcription and chromatin structure
… promoters and mark sites of elevated transcription within the human genome. Although numerous studies have indicated an association between G4 formation and active transcription, the causal nature of this relationship remains unknown. The work in this thesis first addresses whether …
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