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Showing 1 to 10 of 10 for “"transcription cycle"”.
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Structural Studies of Three Factors That Affect the Prokaryotic Transcription Cycle; Microcin J25, LAMBDA Q and T4 GP33
… three factors that affect the prokaryotic transcription cycle; Microcin J25, a peptidyl inhibitor of RNAP; Q antiterminator protein, a bacteriophage protein that modifies RNAP to readthrough termination signals in phage late genes; and Gp33, a T4 phage protein that is a co-activator of T4 …
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An Investigation Into The Role Of Cfia 3' End Processing Complex In The Termination And Initiation/reinitiation Of Transcription
<p>In budding yeast, as in higher eukaryotes, transcription of protein coding genes is executed by a highly specialized, conserved polymerase called RNA polymerase II (RNAPII). The transcription cycle of RNAPII has four major steps: initiation, elongation, termination, and reinitiation. The …
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RNA Polymerase II control in the changing transcriptional landscape
… organism, and it is primarily achieved at the transcriptional level. Transcriptional control is essential as cells adapt to changing conditions, ranging from undergoing differentiation, reacting to signalling cascades, or responding to stimuli. Traditionally, transcription regulation was …
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A Structural Perspective on Bacterial Transcription
<p>Transcription is a highly conserved process that lies at the very center of biology. As in the other two domains of the tree of life, bacterial transcription is a multistep process. In the first step, RNA polymerase (RNAP) contacts with the promoter DNA are established and then must be broken …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
… the size and number of nucleolus (sites of RNAP1 transcription) have been as the marker for the aggressive tumours. The nucleolus size correlates with the level of rRNA transcription and the level of ribosome biogenesis. In recent years the rRNA transcription has emerged as novel target for …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
Signal-induced transcriptional programs regulate critical biological processes through the precise spatio-temporal activation of inducible gene programs. Understanding the dynamics by which RNA Polymerase II precisely induces transcription to activate these programs is important for dissecting the …
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Characterization of the Association of mRNA Export Factor Yra1 with the C-terminal Domain of RNA Polymerase II in vivo and in vitro
… to differential phosphorylation throughout the transcription cycle. Several RNA processing factors have been shown to bind the appropriately phosphorylated CTD, and this facilitates their localization to nascent pre-mRNA during transcription. In <italic>Saccharomyces cerevisiae</italic>, the …
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Multiple regulatory layers in the establishment of Rbfox2 splicing networks
… We also investigated mechanisms of co-transcriptional splicing regulation by Rbfox2. Using chromatin immunoprecipitation, we found that Rbfox2 is recruited early in the transcription cycle to active promoters and transcriptional enhancers, likely via interaction and co-transcriptional …
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Studies into Transcriptional Pausing Regulators and Drug Resistance in Mycobacterium Tuberculosis
… needed. Considering this, we are studying the transcription cycle of Mtb, which is regulated differently than the well-studied model bacterium Escherichia coli (Eco). While transcription initiation is well characterized in the field, later steps like elongation, pausing, and termination remain …
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Factors and mechanisms of archaeal transcription termination and DNA repair
… interactions with RNAP at all stages of the transcription cycle- initiation, elongation, and termination. While studies of transcription initiation and elongation have identified multiple regulatory transcription factors and defined mechanisms, only a handful of protein factors able to …