Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"transcription coupled repair"”.
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Identifying unique cell states in early liver oncogenesis with transcription coupled repair
… cells preferentially enter specific transcriptional states that interact with driver mutations to promote tumourigenesis. Characterising the aberrant transcriptional pathways of initiating cells could help elucidate the mechanisms for determining exactly which mutated cells will go on …
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EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION
<p>DNA double strand break (DSB) repair is critical to maintain genomic integrity and cell viability. DSBs can occur during the course of cell cycle during replication or transcription, or by exogenous agents such as chemicals or ionizing radiation. For my thesis, I studied homologous recombination …
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REGULATORY MECHANISMS OF TRANSCRIPTION AND ASSOCIATED DNA REPAIR
Transcription is a crucial regulatory step in gene regulation modulated by several proteins. Any misregulation during transcription can lead to many diseases including cancer, neurodegenerative disorders and aging making it imperative to have a detailed mechanistic view of the process. Over the …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
Nucleotide excision repair (NER) is a multi-step cellular process that removes bulky and/or helix-distorting DNA lesions, such as UV induced cyclobutane pyrimidine dimers (CPDs) and bulky chemical adducts. Transcription coupled repair (TCR) is a subpathway of NER dedicated to rapid removal of …
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Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast
ABSTRACT Nucleotide excision repair (NER) is a highly conserved DNA repair mechanism which deals with a wide variety of bulky, helix-distorting lesions, such as UV-induced cyclobutane pyrimidine dimers (CPDs). NER is traditionally grouped into two pathways: global genomic repair (GGR), which is …
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Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor
… effects in malignancies with defective DNA repair, specifically those with <em>BRCA1/2</em> (breast cancer, early onset 1/2)<em> </em>mutations. Further evaluation of these inhibitors has shown multiple mechanisms of sensitivity, all of which are associated with the DNA damage response and …
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Understanding the biological processes underpinning neurodegeneration in Xeroderma Pigmentosum
… a rare genetic disorder of nucleotide excision repair (NER). XP is classified into eight complementation groups, XP-A to XP-G and V, depending on the protein component of the NER pathway that is defective. NER is split into two branches. Transcription coupled repair (TC-NER), which rapidly …
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Factors and mechanisms of archaeal transcription termination and DNA repair
… interactions with RNAP at all stages of the transcription cycle- initiation, elongation, and termination. While studies of transcription initiation and elongation have identified multiple regulatory transcription factors and defined mechanisms, only a handful of protein factors able to …
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A Structural Perspective on Bacterial Transcription
<p>Transcription is a highly conserved process that lies at the very center of biology. As in the other two domains of the tree of life, bacterial transcription is a multistep process. In the first step, RNA polymerase (RNAP) contacts with the promoter DNA are established and then must be broken …