Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"transcription activator-like effector nuclease (TALEN)"”.
-
Probing single-molecule dynamics of molecular motors and gene editing proteins
… (CRISPR)/CRISPR-associated protein 9 (Cas9) and transcription activator-like effector nuclease (TALEN). Genome editing critically relies on selective recognition of target sites with minimal off-target effects. However, despite recent progress, the underlying search mechanism of genome editing …
-
Engineering of transcription activator-like effector nucleases (TALENs) for targeted genome editing
… This thesis describes my efforts on engineering transcription activator-like effector (TALE) nucleases (TALENs) as an efficient tool for targeted genome editing. Targeted genome engineering relies on the introduction of a site-specific double-strand break (DSB) in a pre-determined genomic locus …