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Showing 1 to 17 of 17 for “"transannular"”.
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Transannular Interactions in Bifunctional Medium Ring Compounds
Made available in DSpace on 2014-12-05T19:37:17Z (GMT). No. of bitstreams: 1 6000217.pdf: 3799361 bytes, checksum: 4ec9469524ea32963d53ca89ca158919 (MD5) Previous issue date: 1959
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Transannular Interaction Between Nitrogen and Multiple Bonds
Made available in DSpace on 2014-12-05T19:37:34Z (GMT). No. of bitstreams: 1 6100101.pdf: 4665679 bytes, checksum: 4a96bc87bfbff397fb51faf3b6102286 (MD5) Previous issue date: 1960
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I. Transannular Sulfoxide - Ketone Interaction. Ii. A Prospectus of the Vancomycin Structure
Made available in DSpace on 2014-12-05T19:38:02Z (GMT). No. of bitstreams: 1 6206166.pdf: 4399515 bytes, checksum: c7ff8da0afe1b70c28dc46e03a1d12fa (MD5) Previous issue date: 1962
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The mechanism of the reaction of aryl halides with metallic amides. II. Transannular effects in the solvolysis of cis- and trans-cycloöctene oxide
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1954
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Towards the synthesis of RP66453
… biaryl macrocyclic ring via a radical induced transannular ring contraction of a halogenated benzyl aryl ether. Also described are model studies towards the formation of the biaryl linkage via phenanthrene formation, accessed in turn from a radical induced transannular ring contraction of a …
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I SYNTHESES OF SELECTIVELY FUNCTIONALIZED 9(ANE)NITROGEN(3) AND 12(ANE)NITROGEN(3) CYCLIC TRIAMINES II SYNTHESES, COMPLEXATION, AND CONFORMATIONAL STUDIES OF SOME AZAPODANDOCORONANDS (TRANSANNULAR, TRICYCLICORTHOAMIDE, AMIDINIUM SALTS)
… terms of relevant stereoelectronic effects and transannular interactions. The synthetic methodology by which these compounds provide routes to selectively protected cyclic triamines is discussed relative to the preparation of selectively functionalized azapodandocoronands and other compounds of …
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Integration Of Fermentation And Organic Synthesis: Studies Of Roquefortine C And Biosynthetic Derivatives
… compounds, namely through a nitrone-promoted transannular rearrangement. This type of internal rearrangement has never been carried out synthetically and would provide an efficient stereoselective synthesis of triazaspirocycles. This work encompasses efforts towards elucidating the …
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THREE STUDIES OF 2-PYRIDONE PHOTOADDUCT REACTIVITY
… with furans. Cycloaddition of viii yields ix. Transannular closure of ix produces triquinane x, a model system for total synthesis of crinipellin A xi.
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Total synthesis of macrocyclic bisbibenzyl natural products
… regioselective halogenation and radical induced transannular ring contraction. This work also furnished a number of highly strained macrocycles as precursors to the natural products. These structures were found to contain boat-shaped aromatic rings, in addition to twisted olefin functionalities. …
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Synthetic Work Towards Salvinorin A
… in 2007 by the David Evans group utilizing a transannular bis-Michael reaction to create the tricyclic skeleton in one step from a 14-member macrocycle. A second total synthesis was achieved by the Hagiwara group in 2008 via simple step-wise transformations. While these syntheses are useful, …
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… by the controlled installation of the labile transannular hemiacetal motif. Late-stage diversi cation then provides ready access to the congeneric (+)-actinoallolides B-E. The unknown mechanism of action of the actinoallolides poses a barrier to their potential utilisation as lead compounds …
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Total synthesis of ferrugine and synthetic studies towards ferrugine and stemofoline
… system was achieved using a transannular photomediated cyclisation of a carbamoyl radical, generated from a carbamoyl diethyldithiocarbamate, onto an unactivated pendant alkene, followed by group transfer of the dithiocarbamate moiety. The carbamoyl radical cyclisation …
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Synthesis and anticancer evaluation of agelastatin alkaloid derivatives and enantioselective total synthesis of aspidosperma alkaloids
… followed by a highly stereoselective transannular cyclization is described. The versatility of this approach is highlighted by divergent synthesis of the archetypal alkaloid of this family, (+)-aspidospermidine, and an A-ring oxygenated derivative (+)- deacetylaspidospermine, the …
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Mechanistic investigation of the interrupted Bischler-Napieralski reaction and its application to the total synthesis of the aspidosperma alkaloids
… available C21-oxygenated lactam, followed by transannular cyclization and in situ trapping of a transiently formed C19-iminium ion, expediently provides access to the hexacyclic C19-hemiaminal ether alkaloids (+)- fendleridine, (+)-acetylaspidoalbidine, and (+)-limaspermidine. A highly …
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An Investigation of Gold(I) Catalyzed Cycloaddition Reactions
… proceeded to react with the furan moiety to give transannular [4C+3C] cycloaddition products. In addition, the tricyclic ring system with an oxabicyclo-[3.2.1]octadiene and a fused 6-membered ring was produced efficiently using the readily available propargyl ester-furan substrate in the presence …
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Total synthesis of polycyclic natural products : synthetic studies on (+)-ineleganolide, (–)-sinulochmodin C, verrillin hydrate, and aleutianamine.
… natural products leveraging selective transannular cyclization reactions. Our pioneering efforts in this area eventuated in the total syntheses of (+)-ineleganolide and (–)-sinulochmodin C, two coveted natural products that had previously evaded multiple total synthesis efforts. This …
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Stress relief: Exercising Lewis acid catalysis for donor-acceptor cyclopropane ring-opening annulations, a basis for new reaction methodologies
… scaffolds. Traditionally, cycloadditions, transannular transformations, and annulation reactions serve as powerful methods for polycyclic formation. In order to assemble diverse polycycles, donor-acceptor cyclopropanes are useful, versatile synthetic equivalents for C-C bond formations. By …