Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"transamination"”.
-
Characterization of Enzymes in the L-Asparagine Metabolism Pathway in Legumes
… through two major pathways: deamidation and transamination. The transamination pathway employs an unidentified α-ketosuccinamate (α-KSM ) reducing dehydrogenase (α-KSDH), as well as an ω-amidase which has not been fully characterized. Additionally, α-ketosuccinamate and α-hydroxysuccinamate …
-
Predicting post-absorptive amino acid supply to the mammary tissue
… which occurred via efflux stimulation and transamination downregulation. In study 2, we aimed to identify the effects of 10 EAA and 2 Tyr (CDENSPY) on transport rates and transporter regulation (mRNA expression and protein abundance). Within the physiological AA concentrations used, we were …
-
Exploration of mild and selective hydrozirconation reactions facilitated by zirconocene hydride catalysts generated in Situ.
… reduction of 2° amides and the partial reductive transamination of 3° amides. These findings guided our later studies on the direct catalytic conversion of esters to imines and enamines. In addition to carbonyl reduction, we have utilized ZrH catalysis to achieve the catalytic partial …
-
PART I: ALDOL REACTIONS OF 1,3-OXATHIOLAN-5-ONES. PART II: CAMPHOR AS A CHIRAL DIRECTING AGENT IN ALKYLATIONS OF GLYCINATES.
… with no loss of stereochemical integrity. Transamination of the camphor imines to amino esters and amino alcohols can be achieved with hydroxylamine acetate.Dept. of Chemistry and Biochemistry. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: …
-
Metal complexes as models for vitamin B₆ catalysis
… compounds in nonenzyrnatic transamination and reinforces in semiquantitative fashion the prevailing model of ligand electronic features requisite to catalytic activity of these compounds.
-
Co-reactant interactions with CVD surfaces: Activation or passivation of growth
… requirement for NHx species to drive precursor transamination pathways; and (iii) the ability of ammonia to bind with acidic OH groups on oxide surfaces, which completely extinguishes film nucleation and affords a new and effective method for area-selective film growth. In addition, we …
-
NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… demonstrate that targeting glutamine dependent transamination reactions depletes antioxidant defenses in PDA and sensitizes tumors, but not normal tissue, to ß-lap-induced programmed necrosis in vitro and in vivo. Downstream of ROS formation, another mechanism by which tumors can attenuate ß-lap …
-
Excretory nitrogen metabolism in the Chinese soft-shelled turtle, pelodiscus sinensis
… ammonia toxicity was ameliorated by increased transamination and synthesis of certain amino acids in the liver and muscle. Turtles exposed to a progressive increase in salinity through a 6-day period had significant increases in plasma osmolality, [Na+] and [Cl-] by day 6. Free amino acids and …
-
New Strategies and Transformations for the alpha-Functionalization of Amines to Access Chiral Amines
… This thesis work is inspired by the vitamin B6 transamination process: forming ketimines or aldimines to increase the acidities of alpha-C–H protons of amines, thereby enabling the alpha-C–H deprotonation accessible under mild reaction conditions for further derivation. Based on this known …
-
Ultraconformal chemical vapor deposition and synthesis of transition metal nitride films
… 300 °C. Film growth likely proceeds via rapid transamination of the highly reactive precursors with NH3 to afford metal amido fragments with high sticking coefficients and low surface mobilities. Carbon contamination in the films is minimal for manganese, iron, and cobalt nitrides, but similar …
-
Robust Processes for Polymer Modification and Pharmaceutical Synthesis
… of a selective enzymatic acylation followed by transamination to yield the final drug product. Both steps have been successfully performed on a decagram scale: the first step at 200 g and the second step at 80 g. Overall, molnupiravir has been obtained in a 41% isolated yield over two steps …
-
Biosynthetic studies of lincomycin A, a thiosugar-containing natural product
… including epimerization, dehydration and transamination were also demonstrated via the catalysis of enzymes LmbM, LmbL/Z and LmbS, respectively. How the C-1 sulfur is incorporated into the highly decorated GDP-octose is the most intriguing question in the biosynthesis of lincomycin A. …
-
Catalysis, Synthesis, and Materials in Support of Chemical Understanding and Global Health
… a selective enzymatic acylation followed by transamination to yield the final drug product. Both steps have been successfully performed on decagram scale: the first step at 200 g, and the second step at 80 g. Overall, molnupiravir has been obtained in a 41% overall isolated yield compared to …
-
Syntheses, properties, and reactions of transition metal complexes of di(tert-butyl)amide and 2,2,6,6-tetramethylpiperidide
… species, which are the expected products of the transamination of M[N(t-Bu)2]2 compounds with NH3. Treatment of MnBr2(thf)2, FeBr2(dme), and CoBr2(dme) with two equivalents of lithium 2,2,6,6-tetramethylpiperidide, Li(tmp), in pentane, followed by sublimation in static vacuum, affords the new …
-
Synthesis, characterization and chemical vapor deposition of transition metal di(tert-butyl)amido compounds
Although the transition metal chemistry of many dialkylamido ligands has been well studied, the chemistry of the bulky di(tert-butyl)amido ligand has been largely overlooked. The di(tert-butyl)amido ligand is well suited for synthesizing transition metal compounds with low coordination numbers; …