Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"transactivation assay"”.
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Mapping Domains for ZIC3 Molecular Function
… well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and arrangement of visceral organs. Mutations in Zic3 in humans and …
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Mapping Domains for ZIC3 Molecular Function
… well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and arrangement of visceral organs. Mutations in Zic3 in humans and …
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Genetic, environmental and life-style effects on androgen receptor function
… on reproductive characteristics in men. The transactivation assay included a reporter gene with a human androgen responsive promoter. Cells were transfected with vectors having CAG numbers of 16, 22 or 28, representative of the human range. To explore the association between CAG number and …
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Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo
… human androgen responsive promoter was used in a transactivation assay. The repeat lengths included were 16, 22 and 28 CAG, which represent a short, the median, and a long repeat within the normal human range. The study showed that the AR with median repeat length had the highest activity in …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… TKI action. A standard PPARγ competitive binding assay was conducted to assess whether three multi-target TKIs and ENL were PPARγ agonists. Binding affinity to the rosiglitazone binding site of PPARγ was low. However, a PPARγ transactivation assay and PPARγ-related biological functional assays, …
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Functional analysis of MYB112 transcription factor in the model plant Arabidopsis thaliana
… (Affymetrix ATH1 micro-arrays and qRT-PCR) and transactivation assays in leaf mesophyll cell protoplasts. We show that MYB112 binds to an 8-bp DNA fragment containing the core sequence (A/T/G)(A/C)CC(A/T)(A/G/T)(A/C)(T/C). By electrophoretic mobility shift assay (EMSA) and chromatin …