Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"trans-signaling"”.
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
… this is due to blockade of classical<em> </em>signaling, mediated by membrane-bound IL-6 receptor alpha (mIL-6Rα), or trans signaling, mediated by soluble IL-6Rα (sIL-6Rα). Our study assessed the role of sL-6Rα in IPF. We demonstrated elevations of sIL-6Rα in IPF patients and in mice during the …
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Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
… cell line (BV.2), we found that the IL-6 trans-signaling pathway stimulated MHC-II, a marker of activation. While microglia isolated from aged IL-6 knock-out animals displayed significantly less MHC-II expression. Additionally, IL-6 knock-out animals were refractory to LPS-induced sickness …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
… sensitivity to Ca++ leading to mitochondrial transition, elevations in circulating cytokines, including IL-6, independent of gross pulmonary injury, as well as coronary vascular dysfunction. Furthermore, we uncovered a relationship between PM exposures and up-regulation of IL-6 …
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Pilotstudie zur Untersuchung des Effekts von sgp130Fc auf die Periimplantitis im Mini-Schwein
Das IL6-trans-signaling spielt eine entscheidende Rolle in der Pathophysiologie des entzündlichen Prozesses der Periimplantitis. Ziel der Pilotstudie und dieser Arbeit war die Evaluation der Wirksamkeit von sgp130Fc als lokales Therapeutikum im Vergleich zum konventionellen Behandlungskonzept im …
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Engineering cytokine immunotherapies via cell surface targeting
… to modulate lymphocyte behavior. However, translation of cytokines as systemically administered immunotherapies has been severely limited by on-target/off-tissue toxicity. One approach to overcome this challenge is to engineer cytokines for intratumoral retention following local …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
<p> <p>Adenosine is a purinergic signaling molecule that regulates various aspects of inflammation and has been implicated in the pathogenesis of chronic lung diseases. Previous studies have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> …
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Improving sulforaphane bioavailability from cooked broccoli
… action may be through inhibition of the IL-6 trans-signaling pathway, as evidenced by reversal of the DSS-increased expression of IL-6, CCR2 and vascular cell adhesion molecule 1 (VCAM-1). Our next hypothesis was that the quercetin-3-O-sophoroside (QS), the major flavonoid in broccoli, could …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… and modulating drug-metabolizing enzymes and transporters in eliminating organs. Regulation of hepatic enzymes in these states is relatively well described. However, the magnitude, direction, and mechanisms of renal transporter regulation remain poorly defined. This is despite clinical data …