Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"trans-differentiation"”.
-
LINEAGE TRACING ANALYSIS OF PANCREATIC ACINAR CELL DE DIFFERENTIATION AND TRANS-DIFFERENTIATION IN VITRO AND IN VIVO IN THE ABSENCE OF MIST 1
… suggest that mature pancreatic acinar cells can trans- differentiate into duct and islet cells in vitro; however, the intrinsic factors regulating this process have not been defined. The acinar specific transcription factor MIST1 is required for acinar cell maturation and targeted deletion of …
-
Stromal interactions in pleural mesothelioma
… mesothelial cells. I generated a single cell transcriptomic dataset from both fresh tissue for single-cell RNA-sequencing, and isolated nuclei from frozen samples for single nuclei RNA-sequencing. Following rigorous quality control, I retained 268,089 cells and nuclei across asbestos exposed …
-
Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… expression of vWF indicates the early stages of trans-differentiation of LN229 cells to an endothelial cell phenotype. We then investigated the effect of chemotherapeutic drugs temozolomide (TMZ) and Avastin® on EC networks, LN229 cell morphology and alignment, cytotoxicity, colocalization, and …
-
Investigation of experimental cell lines and non-invasive online sensor technologies in a 3D bioreactor system for extracorporeal liver support therapy
Liver transplantation is currently the only successful treatment to cure acute or acute-on-chronic liver failure. However, the number of patients waiting for a donor organ is constantly rising due to scarcity of organ donations. To overcome this bottleneck different bio-artificial liver …
-
THE ROLE OF ENDOTHELIAL CELLS IN VASCULAR CALCIFICATION
… nature and following particular stimuli they can trans-differentiate and acquire several different phenotypes through the endothelial-to-mesenchymal transition (EndMT). Methods. Human aortic ECs (HAECs) were challenged, in an in vitro calcification model, with 2, 2.5, 3, 3.5 mM Pi for up to 7 …
-
Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
Epithelial-mesenchymal transition (EMT) is a trans-differentiation program essential for development and wound healing that is pathologically activated during cancer progression. During this process, cells undergo complex changes at the transcriptional and translational levels leading to …
-
A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… marker. Furthermore, AIM2 was found to augment transcriptional activity of Wilm’s tumour-1 that regulates Nphs1 expression. This data suggests that non-canonical AIM2 regulates podocyte maturation, proliferation and potentially podocyte-to-parietal cell trans-differentiation during cellular …
-
IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… molecular mechanism by which AIEC induces pTh17 trans-differentiation and activation is still totally unknown. To this aim, a library of 10,000 AIEC-LF82 mutants was generated and screened in order to identify AIEC-virulence determinants specifically involved in pTh17 generation, looking for …
-
Targeted Differentiation of Primary Head and Neck Squamous Cell Carcinoma Cells
… cells and analyzed the mechanisms underlying differentiation using ATAC and RNA sequencing. Immunofluorescence verified the results using human HNSCC tissue from different anatomical locations. This research discovered that when HNSCC cells are differentiated, they become more adherent, stop …
-
UNRAVELLING SEX-DEPENDENT MECHANISMS IN CALCIFIC AORTIC VALVE STENOSIS
… local inflammation and interstitial cells (VIC) differentiation into myofibroblasts and osteoblasts. Activated valve endothelial cells, undergoing endothelial to mesenchymal transition (EndMT), begin to express mesenchymal adhesion molecules and facilitate monocytes infiltration and local …
-
Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration
… secreted factors that promote cholinergic differentiation during postnatal skeletal development, and to examine the function of the cholinergic system in bone using genetic and pharmacological depletion of cholinergic neurons. Treatment of superior cervical ganglion cultures with …
-
Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… underlying mechanisms. Epithelial-mesenchymal-transition (EMT) is a naturally occurring and strictly regulated trans-differentiation process essential for tissue morphogenesis during early embryonic development. Recent studies suggest that aberrant reactivation of EMT in adults may be a key …