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Showing 1 to 6 of 6 for “"trans-cyclooctene"”.
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Site-specific immobilization of tetrazine-modified green fluorescent protein on trans-cyclooctene surfaces
… a glass support substrate with one of several cyclooctene compounds (patterned through micro-contact printing, or un-patterned by simple immersion), followed by reaction in these functionalized areas with a site-specifically modified tetrazine-protein moiety, either through ‘click chemistry’ or …
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Synthetic Studies. Part I - Precursors to Trans-Cyclooctene and the Trans-Bicyclo(6.1.0)nonane System. Part Ii - Cis and Trans Ethylidenecyclopropane-2,3-Dicarboxylic Acids
Made available in DSpace on 2014-12-10T23:01:21Z (GMT). No. of bitstreams: 1 7219842.pdf: 7818661 bytes, checksum: 045211f60069a1ba95ee5768e7dd2de1 (MD5) Previous issue date: 1972
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Interfacial bioorthogonal chemistry for biomaterials synthesis and patterning and development of catalytic method for "turning-on" the tetrazine ligation
The bioorthogonal trans-cyclooctene-tetrazine ligation has emerged into a powerful tool in the field of biomedical research. The development and the versatile applications of tetrazine ligation was made possible by the advancement of trans-cyclooctene synthesis. Based on the previous art of …
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Developing unstrained alkenes and alkynes for bioorthogonal chemistry
… dienophiles. Strained dienophiles, for example, trans-cyclooctene derivatives, can undergo ultrafast IEDDA reactions and therefore have been extensively developed. Unstrained alkenes and alkynes, however, have not been well investigated as IEDDA handles. In general, unstrained dienophiles are …
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
… relates to the development of both vinyl and trans-cyclooctene (TCO) protecting groups to mask a carboxylic acid-containing anti-inflammatory drug. In each case, the prodrug stability, reaction profile and kinetics of decaging were studied with a range of tetrazines. Whilst vinyl esters …
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Synthesis and utilization of N-acetyl muramic acid derivatives as tools for probing information about peptidoglycan structure, biogenesis and immunological response
… and N-acetylmuramate alpha-1-phosphate uridylyltransferase, MurU) I developed bacterial strains and protocols that facilitated more efficient utilization of NAM probes. Finally, I collaborated with the Fox lab at UD to develop a new bioorthogonal NAM probe. This probe capitalized on the …