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Showing 1 to 11 of 11 for “"tranexamic acid"”.
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The Effect of Topical Tranexamic Acid Application on Melasma Treatment
… hyperpigmentary disorder mainly on the face. Tranexamic acid (TA), a plasmin inhibitor, has been suggested as an efficient treatment modality on melasma. The aim of this study was to investigate the effects and action mechanism of topical TA in the treatment of melasma. Material and methods: …
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Tranexamic Acid Modulation of Excitatory and Inhibitory Amino Acid Receptors: A Potential Mechanism for Postoperative Seizures
Tranexamic acid (TXA) is an antifibrinolytic drug that is used worldwide to reduce blood loss in a variety of hemorrhagic conditions. TXA causes seizures and myoclonic spasms, particularly during the postoperative period, and these seizures are associated with a higher incidence of neurological …
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Use of Topical (Intra-articular) Tranexamic Acid to Minimise Blood Loss and Transfusion in Total Knee Replacement Surgery
… allogeneic transfusion is not risk free. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent used intravenously to stop bleeding in TKR and other surgical procedures. Objectives To determine whether intra-articular TXA is effective, safe and cost-effective in reducing blood loss …
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The Effect of Tranexamic Acid on Transfusion Requirement in Dual Antiplatelet-Treated Anemic Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
… aim of this study was to evaluate the effect of tranexamic acid (TA) on blood loss and transfusion in preoperatively anemic patients who continued their dual antiplatelet therapy until within 5 days of off-pump CABG (OPCAB). Methods and Results: Seventy-six anemic patients were randomized into …
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Beneficiation of selected pesticides and an antihyperlipidemic agent via cyclodextrin complexation and co-crystallization
… 4-aminopyridine, benzamide, isonicotinamide, tranexamic acid and urea. NMR spectroscopy revealed 1:1 stoichiometries for all products. Their designation as salts or co-crystals was based on unequivocal evidence gleaned from single crystal X-ray structural studies, these assignments being …
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Evaluation of the Role of Endogenous Factor XIII as a Determinant of Bleeding-Related Outcomes and Death Among Severely Injured Patients
… measurements, and cohorts of patients where tranexamic acid was not consistently provided. Future research is needed in the form of a prospective international longitudinal cohort study to determine the natural history and potential clinical relevance of FXIII in a large, contemporary and …
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Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
… with the antifibrinolytic agents 6-aminocaproic acid [(S-IBU)- (ACA)+ ] and tranexamic acid [(S-IBU)- (TXA)+ ] were successfully synthesised and comprehensively characterised. A second crystalline form of a cyclodextrin inclusion complex between S-IBU and heptakis(2,6-diO-methyl)-β-cyclodextrin …
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Relato de caso: manejo anestésico de nefrectomia com trombectomia cavoatrial sob circulação extracorpórea
… and target-controlled infusion of remifentanil. Tranexamic acid was administered at 2 mg/kg/h. Three units of packed red blood cells were transfused, 560 mL was reinfused via intraoperative blood salvage, and 1,000 IU of prothrombin complex concentrate was administered. Calcium replacement was …
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An audit of uterotonic use for the prophylaxis and treatment of haemorrhage at caesarean delivery at Mowbray Maternity Hospital, Cape Town, South Africa
… (13 women), syntometrine (three women) and tranexamic acid (one woman). Additional surgical measures required were B-Lynch compression suture for one, and haemostatic sutures for two. There were no re-look laparotomies or hysterectomies during the study period and there were no major …
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Factores de riesgo para convulsiones tras cirugía cardiaca con acido tranexamico: estudio de casos y controles, FCI
La cirugía cardiaca con circulación extracorpórea tiene riesgo de lesión del sistema nervioso central que impacta negativamente el desenlace postoperatorio. Su espectro es variable siendo lo más frecuente la lesión isquémica. Sin embargo esta no es la única complicación neurológica, las …
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Evaluación de los antifibrinolíticos tópicos en cirugía cardíaca: revisión sistemática, metaanálisis y análisis secuencial de ensayos
Introducción: Los antifibrinolíticos análogos de lisina (LAAF), como el ácido tranexámico (TXA) y el ácido épsilon-aminocapróico (EACA), ayudan a reducir la pérdida de sangre en cirugía cardíaca de alto riesgo. Estos agentes inhiben la fibrinólisis, disminuyendo el sangrado y la necesidad de …