Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"trained immunity"”.
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Metabolic regulation of trained immunity in atherosclerosis
Contains fulltext : 250459.pdf (Publisher’s version ) (Open Access)
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… analysis revealed that lipid peroxidation and trained immunity mediate noncanonical pyroptosis in diet induced NALFD.
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… in bone marrow-derived macrophages, resulting in trained immunity, known to occur in immune cells due to persistent metabolic and epigenetic changes. Data from this study suggest that chronic moderate exercise can influence the inflammatory responses of macrophages by reprogramming their metabolic …
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Effect of Systemic Versus Localized Bacillus Calmette-Guérin Immunotherapy on Bladder Cancer Progression: Novel Role for Trained Immunity
… niche. Furthermore, we investigated the role of trained immunity, also known as innate immune memory, as a potential mechanism through which BCG-induced systemic immunity leads to local anti-tumour effects. Our study indicates that co-instillations of cancer cells and BCG-trained macrophages lead …
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… system was considered to be the sole arm of immunity that can form a memory of past infections. In recent years this paradigm has been contested, following discoveries that many innate immune cells display lasting changes in their responses to challenges as a consequence of previous …
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Microbiota-host interactions and infection dynamics in critical illness.
… phenotype occur in the bone marrow though “mis-trained immunity” via metabolic and epigenetic programming. Taken together, these findings further establish intestinal dysbiosis in critical illness as a driver of neutrophil dysfunction, with metabolic and epigenetic reprogramming of neutrophils …
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Understanding the Role of Mitochondria in Driving Antiviral Inflammatory Responses
… in aged macrophages. BCG is a potent inducer of trained immunity and was used during the COVID-19 pandemic to protect against severe disease. Interestingly, we found that BCG treatment in vivo induced a trained phenotype in cells stimulated with TLR7 ligands and a tolerant phenotype following …