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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"toxoplasmosis"”.
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Lymphocyte-Macrophage interactions and resistance to Toxoplasmosis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis
Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the …
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Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice
Toxoplasma gondii is an intracellular parasite that causes persistent, lifelong infection in one-third of humans worldwide. The parasite converts from a lytic, actively replicating form (tachyzoite) into a latent tissue cyst form (bradyzoite) that evades host immunity and is impervious to current …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
The cytokine IL-27 is a potent negative regulator of the inflammatory response to the pathogen Toxoplasma gondii, and the majority of the studies on IL-27 during this infection have focused on its ability to limit T cell responses. The basis for this suppressive activity is unclear, but it was …
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Studies on murine toxoplasmosis: the use of active immunization to prevent congenital transmission
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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A light and electron microscope investigation of the host-parasite relationship in the brains of mice with congenital toxoplasmosis.
… cysts in the brains of mice with congenital toxoplasmosis, with reduced silver salts and protargol silver suggested that it was composed, at least in part, of components derived from the neuronal cytoskeleton. Electron microscopy extended these observations and revealed that intact tissue …
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Evaluation of the level of awareness of congenital toxoplasmosis and associated practices among pregnant women and health workers in Tanzania's Temeke District
Toxoplasmosis is a zoonotic disease caused by an intracellular obligate coccidian protozoan called Toxoplasma gondii. The parasite infects all warm blooded animals and usually develops in immune-compromised hosts. The risk groups are pregnant women, children and HIV/AIDS patients. Congenitally …
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Ocorrência de toxoplasmose em pacientes atendidos no Hospital Universitário Lauro Wanderley.
Toxoplasmosis is a protozoan with high seroprevalence rates, which etiological agent is Toxoplasma gondii, but the severe clinical conditions are more often diagnosed in newborns and immunocompromised , Therefore, this study aimed to investigate the occurrence in toxoplasmosis seropositive …
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Elucidating the Role of the Essential Kinase TgGSK in the Human Parasite Toxoplasma Gondii
… or immunosuppressed individuals can lead to toxoplasmosis, which can include brain lesions and lead to death. Similarly, toxoplasmosis can result in birth defects, brain swelling, and blindness of a developing fetus in the case of a congenital infection. With minimal treatments for …
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Soropositividade de anticorpos anti-Toxoplasma gondii e anti-Trypanosoma cruzi em populações ribeirinhas do recôncavo baiano
Chagas disease (CD) and toxoplasmosis are parasitic zoonoses with a major public health impact, particularly in regions with unfavorable socioeconomic conditions. Riverside populations may be more exposed to infectious agents due to environmental and sanitary factors, and limited access to health …
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Development of a Canine Coccidiosis Model and the Anticoccidial Effects of a New Chemotherapeutic Agent
… ponazuril to prevent and treat acute and chronic toxoplasmosis was investigated. Mice treated prophylactically with ponazuril were completely protected from developing an acute T. gondii infection. Fatal toxoplasmosis was prevented in mice starting treatment 3 and 6 days post infection at a dose …
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Farnesyl Pyrophosphate/geranylgeranyl Pyrophosphate Synthase of Toxoplasma Gondii: Its Role in the Parasite Isoprenoid Pathway and as a Target for Bisphosphonates
… represents a new approach to chemotherapy of toxoplasmosis with a group of safe and easy to prepare compounds.
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Sphingolipid synthases of Toxoplasma gondii and other organisms
… parasite of the phylum Apicomplexa, and toxoplasmosis is an important disease in immuno-compromised individuals - especially AIDS patients, organ transplant recipients and patients receiving anti-cancer chemotherapy. Toxoplasmosis also has economic importance as it results in spontaneous …
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An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue
… in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 72 lung biopsy samples acquired from patients. This compared with 10% in healthy controls. Little is known of immune mechanisms acting on T. gondii infected lung tissue. Research on rat and mouse models …
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ΕΠΙΔΗΜΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΤΟΞΟΠΛΑΣΜΩΣΕΩΣ ΣΕ ΔΥΟ ΝΟΜΟΥΣ ΤΗΣ ΕΛΛΑΔΟΣ
… STUDY WAS THE EPIDEMIOLOGICAL INVESTIGATION OF TOXOPLASMOSIS IN TWO PROVINCES OF GREECE. THE AUTHOR EXAMINED A TOTAL OF 2.372 PERSONS; 1.101 SERA WERE COLLECTED IN THESPROTIA AND 1.N AETOLOAKARNANIA THE STUDY INCLUDED: A) SEROLOGICAL EXAMINATION WITH IF AND THE REMINGTON TEST. B) …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… gondii TS inhibitors for the treatment of toxoplasmosis.</p><p> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase (TS) inhibitors prevent cell division by interfering with de novo thymidylate synthesis. Antiangiogenic agents target …
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Pediatric uveítis : experience in colombia
… common etiology was infection (58.4%) caused by toxoplasmosis (76.8%). There was a statistically significant difference in visual acuity between anterior (20/68) and intermediate uveitis (20/70), compared with posterior uveitis (20/434) (p<0.05). Conclusions: This is the first study to report the …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… American trypanosomiasis (Chagas' disease), toxoplasmosis, leishmaniasis, and malaria, respectively. The studies contained within this thesis were carried out in three main areas: (a) demonstration of selective anti-parasitic activity of bisphosphonates, (b) elucidation of molecular mechanism …
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Seroprevalence of anti-toxoplasma IgG antibody in HIV patients with neurological manifestations
… to opportunistic Infections such as Cerebral Toxoplasmosis. In patients with the acquired immunodeficiency syndrome (AIDS), toxoplasmic encephalitis (TE) is usually a presumptive diagnosis based on positive anti-toxoplasma Antibody (Ab), clinical manifestations and characteristic …
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Stroke in the young adults at the University Teaching Hospital, Lusaka
… normal except for one patient who had suspected toxoplasmosis. Many patients had anemia of chronic ill health and generally reported late to the hospital.HIV is strongly associated with strokes in the young adults.
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