Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"toxin activity"”.
-
Anti-<i>Candida a</i>ctivity of killer toxins from the yeast <i>Williopsis mrakii</i>
Killer yeasts secrete toxins which are lethal or inhibitory to sensitive yeasts but to which they themselves are immune. <i>Williopsis mrakii</i> is a killer yeast but very little is known about the physiology of the organism and the characteristics of its toxin. This research was concerned with an …
-
Engineering Soluble, High Affinity Receptor Antagonists for Bacterial Exotoxins
… for picomolar affinity to staphylococcal enterotoxin B (SEB). As the known contact regions had already been heavily mutagenized, additional engineering of the Vbeta was performed through extension of the CDR1 loop. Soluble forms of the high-affinity Vbeta regions were tested for their ability to …
-
Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
The main determinants in toxin cell specificity are often interactions with surface receptors. It has recently been determined that the membrane phospholipid sphingomyelin (SM) is the primary receptor for the Helicobacter pylori vacuolating cytotoxin (VacA). While the cellular receptor has been …
-
DEVELOPMENT OF SURFACE BASED PLATFORMS FOR BIOMOLECULAR RECOGNITION AND PROTEASE ASSAYS
… novel approaches for the development of protease activity assays. Our focus of study is the protease assay development process on two types of characterized platforms: microspheres and self-assembled monolayers (SAMs) on flat surfaces. The surface preparation and conjugation process with …
-
Regulation of to xin Synthesis By Clostridium Difficile
… strains of <em>C. difficile</em> produce either toxin A and/or toxin B, which are essential for the pathogenesis of this bacterium. Current methods for diagnosing CDI are mostly qualitative tests that detect the bacterium, the toxins, or the toxin genes. These methods do not differentiate …
-
Identification and Characterization of the Helicobacter Pylori Vacuolating Cytotoxin Receptor
… important virulence factors, the vacuolating cytotoxin (VacA), which is the only known exotoxin released by H. pylori into the stomach of infected individuals, contributes to the pathogenesis of infection by directly modulating several important properties of host cells. To be effective, VacA, …
-
Purification and characterization of Clostridium perfringens iota toxin
Clostridium perfringens type E iota toxin is implicated in some cases of fatal diarrhea in calves, lambs, and guinea pigs. A crossreacting "iota-like" toxin, produced by Clostridium spiroforme, is responsible for antibiotic-associated and weaning related enterotoxemias of rabbits. Antisera …
-
Structural and functional characterization of a Xanthomonas Type III effector
… similar to the Zeta-epsilon family of toxin: antitoxin systems from the human bacterial pathogen Streptococcus pyogenes. AvrRxo1 and Arc1 have toxin: antitoxin-like activity in bacteria, and the toxin activity of AvrRxo1 is required for its virulence function in planta. These findings …