Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"toxicokinetics"”.
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Toxicity and toxicokinetics of fenvalerate in fish
<p>The influence of emulsifiers and toxicokinetics on the lethality of pyrethroid insecticides to fish was examined using fenvalerate as a model compound;Flow-through acute toxicity testing with technical grade and a 30% active ingredient emulsifiable concentrate (EC) formulation of the insecticide …
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Nanoparticle toxicokinetics in the nose: an assessment of risk
In recent years there has been a dramatic increase in the number of nanomaterials being developed, thus increasing the need for hazard assessment methods beyond the capacity of toxicological screening methods using animals. Current in vitro assays have a number of shortcomings, which were addressed …
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Toxicokinetics and structure/toxicity relationships of low molecular weight peptide toxins from cyanobacteria
The toxicokinetics of tritiated dihydromicrocystin-LR ( ($\sp3$H) 2H-MCLR) were studied in anesthetized pigs. Two dose groups (75 and 25 $\mu$g/kg) were given radiolabeled plus nonlabeled 2H-MCLR IV and one dose group (75$\mu$g/kg) was given radiolabeled plus nonlabeled 2H-MCLR via an isolated …
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Bioaccumulation and Toxicokinetics of Polycyclic Aromatic Compounds and Metals in Giant Floater Mussels (Pyganodon grandis) Exposed to a Simulated Diluted Bitumen Spill
Canadian bitumen is mainly transported in a diluted form via pipeline and train, all posing a risk as they can lead to the release of diluted bitumen (dilbit) in the environment. In the summer of 2018, a collaborative large-scale field experiment was conducted at the International Institute for …
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Acute Selenium Toxicosis in Sheep
The toxicity, toxicokinetics, and progressive pathological changes produced by sodium selenite in sheep following parenteral administration were evaluated.
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Comparative fates of three structurally distinct PCB congeners in rats and house flies
… rats following iv injection into the tail vein. Toxicokinetics and enzyme-related toxicities of these PCBs were also examined in female house flies following topical application.
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Genetic variability and cadmium metabolism and toxicity
… inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of Cd. This may be due to genetic factors. The aim of this thesis was to identify genetic factors that are associated with Cd metabolism and toxicity. As Cd is a foreign element, there is no endogenous …
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Physiologically-Based Kinetics and Mechanistic Models to Assess Exposure to Chemicals
… growing attention given to exposure-based and toxicokinetics-driven toxicity which has resulted in increasing recent application of PBK modelling. The overall aim of this thesis was to propose novel ways to use publicly available data for the quantitative assessment of adverse effects induced …
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Autoradiographische Untersuchungen zur Toxikokinetik von Myosmin in Ratten
Autoradiographic studies on myosmine toxicokinetics in rats Myosmine, a minor tobacco alkaloid was recently detected in a wide variety of nutritional plants including cereals, nuts, cocoa and dairy products. Under acidic conditions myosmine is easily nitrosated leading to pyridyloxobutylation …
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Interactions of Environmental Pollutants with Human Gut Bacteria
… microbiome dynamics and its role in the toxicokinetics of chemical pollutants.
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Absorption of Dietary Titanium Dioxide
Food grade Titanium dioxide (fgTiO2) is used as a colouring additive in the food industry, and it is present in food, capsules, and toothpaste. We are exposed to a median of 2.5 mg fgTiO2 per day in the UK through such sources. These are persistent micro and nanoparticles that have been reported in …
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Beurteilung von Phyto- und Xenoöstrogenen am Beispiel ausgewählter Substanzen
Bei Daidzein und Bisphenol A handelt es sich um zwei Vertreter einer Klasse von Stoffen, die als „Umwelthormone“ (engl. endocrine disrupter) bezeichnet werden. Aus der Gruppe der Phytoöstrogene wurde Daidzein als wichtiger Vertreter, der in hohen Konzentrationen in vielen Nutzpflanzen und …