Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 89 for “"toxicant"”.
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity. </p> <p>Previous studies suggested that dioxin exposure increased …
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Energetic costs of toxicant metabolism in rainbow trout ( Oncorhynchus mykiss)
… exposed to a variety of environmental toxicants including polychlorinated biphenyls (PCBs). A portion of the energy assimilated by the fish is dedicated to detoxification. This study investigates the changes in energetic demands associated with increased detoxification. Two CYP1A …
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Osmoregulatory role of the intestine in fish physiology. Evolutionary, environmental, and toxicant implications
The earliest fishes arose circa 500 million years ago (mya) during the Ordovician and persevered throughout several mass extinction events. Unknown fishes' lines became extinct in life history (e.g., conodonts, ostracoderms, acanthodians, placoderms, etc.). It is so that extant lineages may be …
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Toxicant-releasing substrates: a new method for delivering copper to microbial communities in SITU
… ecosystems in which the studies are conducted. Toxicant-releasing substrates have been proposed to allow the delivery of different levels of chemical pollutants to replicate microbial communities in situ while minimizing the amount of toxicant released into the aquatic ecosystems under …
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Transcranial Doppler sonography: a new noninvasive method for measuring toxicant-induced alterations in cerebral blood flow
<p>The purpose of this experiment was to use transcranial Doppler sonography (TCD) in the dog to noninvasively measure changes in cerebral blood flow (CBF) resulting from a low-level exposure to the commonly used pyrethroid insecticide deltamethrin. Deltamethrin has previously been shown to …
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Dynamics and optimal harvesting of prey-predator fishery models in the presence of a toxicant using pontryagin maximum principle
… most of the models are taking the existence of a toxicant into consideration, either in an anthropogenic or a self-produced form. In order to account for the intraguild predation interaction that occurs in marine ecosystems, three species fishery models are also studied by modeling the carrying …
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Towards an understanding of the developmental zebrafish (Danio rerio) proteome and impacts of age-specific sensitivities with a model toxicant.
… provides a foundation to further examine how toxicants and toxins influence age-specific adverse outcomes.
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The search for a novel toxicant in Gastrolobium (Fabaceae : Mirbelieae) seed historically associated with toxic native fauna / David E. Peacock.
… the analysis of Gastrolobium seed for possible toxicants which could potentially provide chemical defence compounds for reintroduced fauna.
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Novel approaches to toxicity testing in Daphnia magna
… to use this approach to discriminate between toxicant modes of action (MOA) and to link toxicant induced metabolic effects to reduced reproductive output in D. magna. FT-ICR MS metabolomics was determined to be a feasible approach for toxicity testing of both whole-organism homogenates and …
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Delivery of Smoke Toxicants from Cigarettes Made in Developed and Developing Countries: a comparison of U.S. full flavor and ultra light brands with Syrian cigarettes
… research is needed to understand how cigarette toxicant yield affects smoker toxicant exposure. While there is much clinical research on yield and exposure in developed countries, there is little in developing countries. Forty smokers completed one, 4-hour session to compare yield and exposure …
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Development of methodology for community level toxicity testing using the fathead minnow seven day survival-growth impairment test
… widely used to assess the potential effects of a toxicant on aquatic life. Increasingly, it is necessary to understand how the results of these tests relate to toxicant effects in natural communities. This dissertation presents the methodology and validation for a community level toxicity test …
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… also seen to confer some degree of resistance to toxicant exposure, particularly in the case of ethanol. Using a cell based ELISA for GFAP together with concurrent assays for metabolic activity and cell number, each of the three cell lines responded to toxicant exposure by an increase in GFAP …
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Purification of uridine diphosphate glucuronyltransferase
… phases. In phase I, a functional group on the toxicant is made available for subsequent Phase II reactions. In phase II, the functional groups are conjugated to a compound that will increase the solubility of the toxicant, enhancing its elimination. Uridine diphosphate glucuronyl transferase …
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Circulating sex hormone levels in rats: a systematic analysis of the literature and perinatal BPA study
… role in elucidating the mechanisms by which a toxicant exerts its deleterious effects, as well as serving as a translational system for comparison to human biology. The anatomy, physiology, and molecular mechanisms of the reproductive system of these models should first be well characterized …
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Sediment toxicity and bioaccumulation of toxicants in the zebra mussel, Dreissena polymorpha, at Times Beach, Buffalo, New York
… limits in the water column. In the sediment toxicant concentrations were as high as 549 mg/kg for total PAHs, 9 mg/kg for PCB Aroclor 1248, and 54, 99, 6, 355, 637, and 16 mg/kg for the metals: As, Ba, Cd, Cr, Pb, and Hg respectively. To predict contaminant bioavailability, elutriate and …
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The lethal and sublethal effects of aldicarb on the estuarine grass shrimp, Palaemonetes pugio
… and adult grass shrimp to determine lethal toxicant ranges. LC₅₀ values were 85.0 ug/L for newly hatched larvae, 70.7 ug/L for 22-d old larvae and 125.4 ug/L for adults. The impact of aldicarb on specific neurological functions in the grass shrimp was examined using an acetylcholinesterase …
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THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
Acrolein is an environmental and occupational toxicant known to cause adverse health effects to humans in areas such as the respiratory system, ocular system, and the skin. The NIH’s Chemical Counter-Measures Research Program has taken an interest in acrolein as a toxicant because of the lack of …
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Nash Alters Drug Metabolizing Enzyme and Transporter Expression Resulting in Significant Consequences for Pharmaceutical Disposition and Toxicity
… pharmaceutical or a potentially harmful toxicant. The major cellular effectors of ADME are the drug metabolizing enzymes (DMEs) and transporters. DMEs function to transform xenobiotics into a metabolite that is more suitable for excretion, whereas drug transporters serve a two-fold …
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