Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"toxic shock"”.
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Laboratory Testing of Process Controls for the Mitigation of Toxic Shock Events at Enhanced Biological Phosphorus Removal Wastewater Treatment Plants
Toxic shock events can be detrimental to wastewater treatment systems and can result in long-term losses of system performance. If warned of an impending toxic shock, operators would have the opportunity to implement process controls that could help mitigate the effects of the shock event. The …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… Gram-negative, LPS-lacking bacterium, including toxic shock-like syndrome and liver injury in the absence of overwhelming bacterial burdens, has led to the hypothesis that severe disease is immune-mediated. Our previous studies showed that intraperitoneal infection of wild-type mice with virulent …
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Engineering Soluble, High Affinity Receptor Antagonists for Bacterial Exotoxins
… their ability to inhibit SEB-mediated T cell cytotoxicity in vitro. As the affinity of the Vbeta regions increased, the amount of protein needed to neutralize 50% of the toxin activity correspondingly decreased. These Vbeta regions were also tested in various rabbit models of toxic shock by …
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Streptococcal colonization of host mucosal surfaces: a study of biofilm formation and dispersal
… include pharyngitis, otitis media, sepsis, a toxic-shock syndrome, necrotizing fasciitis, and the post-infectious sequelae acute rheumatic fever and acute rheumatic heart disease. Thus, rather than exploit a singular niche, GAS has evolved to colonize and disseminate within several …
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The relationship between menstrual ideology and practice in the lives of women in South-western Ontario
… abortion, sexuality, work, family relationships, Toxic Shock Syndrome, Polycystic Ovarian disease, menopause, and commercial menstrual care products.
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Outcomes of Beta-Hemolytic Streptococcal Necrotizing Skin and Soft Tissue Infections and the Impact of Clindamycin Resistance
… followed for death, limb loss, and streptococcal toxic shock syndrome (STSS). Surgical wound cultures and resistance data were obtained within 48 hours of admission as part of routine care. Risk ratios for the association between these outcomes and the presence of beta-hemolytic streptococci, or …
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The Feasibility of Bioaugmentation for the Remediation of Chlorinated Solvents: A Microcosm Study
… organisms due to concentration or potential toxic shock. It appears that bioaugmentation is a remediation alternative worthy of further study including possible delivery methods, toxicity or inhibition effects of concentration, and fate/transport studies.
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The role of superantigens during Staphylococcus aureus nasal colonization and infection
… as well as their role in severe diseases such as toxic shock syndrome, the question as to why strains of S. aureus produce SAgs and the role that they play in the life cycle of these bacteria remains unanswered. The contribution of SAgs towards pathogenicity and bacterial survival in vivo were …
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Use of an Animal Model of Group A Streptococcal Infection to Identify Factors Important for Virulence
… (flesh eating disease) and streptococcal toxic shock syndrome (STSS). Virulence of the GAS is multifactorial, as it possesses an array of virulence factors regulated in a coordinated fashion by a complement of transcriptional regulators. A mouse model of streptococcal invasive skin …
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Development of a Human Immune System from Hematopoietic Stem Cells in a Human/Mouse Xenogeneic Model
… antigens. Administration of the super-antigen toxic shock syndrome toxin-1 (TSST-1) resulted in the specific systemic expansion of human Vbeta 2+ T cells, release of human pro-inflammatory cytokines and localized specific activation and maturation of human CD11c+ dendritic cells. These results …
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Detection of staphylococcal enterotoxins in patients with rheumatoid arthritis or closed fracture
… staphylococcal enterotoxins B and C (SEB/SEC), toxic shock syndrome toxin 1 (TSST-1) and alpha haemolysin (AH), members of the pyrogenic toxin superantigen family (PTSAg). To develop a novel mass spectrometry method to analyse and compare urine samples from patients with rheumatoid arthritis …
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Engineering soluble, high affinity T cell receptor domains for detection of staphylococcal and streptococcal exotoxins
… enterotoxins A, B, C (SEA, SEB, SEC), toxic shock syndrome toxin-1 (TSST-1) and streptococcal pyrogenic exotoxins (SpeA, SpeC) that possess superantigenic properties, by virtue of which they stimulate a large fraction of an individual’s T cells, leading to hyperinflammation and in some …
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The characterisation of the cell surface of Staphylococcus aureus in the search for new therapeutic targets
… endocarditis, osteomyelitis, cellulitis, toxic shock syndrome, and necrotising pneumonia. S. aureus is a leading cause of hospital-acquired infections and has rapidly acquired resistance to multiple antimicrobials. As such, it was deemed a serious threat by the Centers for Disease Control …
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Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… such as necrotizing fasciitis, sepsis and toxic shock. Until recently, S. pyogenes has been considered as a strictly extracellular pathogen, but several studies has shown that it is capable of invading and surviving intracellularly in several human cell types. In this thesis I have …
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Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… inflammatory response contributing to septic shock. LL-37 has been studied as an alternative to conventional antibiotics but clinical trials have been hampered by indications of its toxic effect on mammalian cells and evidence that its antimicrobial effects are inhibited by serum. It has been …
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Biochemical and Immunological Mechanisms Underlying Differential Interaction of Superantigens with Host Immunogenetic Factors in Streptococcal Sepsis
… ranging from pharyngitis to streptococcal toxic shock (STSS), which is caused by excessive cytokines responses triggered by streptococcal superantigens (Strep SAgs). SAgs interact simultaneously with HLA class II molecules on antigen presenting cells (APC) and with the T cell receptor beta …
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Charakterisierung der Eigenschaften des Mycoplasma arthritidis Superantigens
… data of growth curves presented here indicate a toxic effect of MAM to E. coli. In comparison with Staphylococcal enterotoxin A and Toxic shock syndrome toxin only MAM inhibits growth and viability of E. coli. No protease-activity of MAM could be detected, but the experimental series revealed …
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Streptococcus pyogenes - a manipulator of human defences
… vascular leakage present in streptococ¬cal toxic shock (STSS). This thesis demonstrates that preformed antibodies against certain epitopes on the M protein contribute to triggering the neutrophils to secrete heparin binding protein, a potent inducer of vascular leakage. This might explain …
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The effect of subinhibitory concentrations of antibiotics on virulence factors of <i>Staphylococcus aureus</i> biofilms
… ability to form biofilm and the superantigen (toxic shock syndrome toxin-1 (TSST-1)) production were evaluated in challenged and control biofilms, eluates and supernatants. Moreover, since sub-MICs of antibiotics have the potential to alter virulence and interfere with metabolic processes of …
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Breakpoint Chlorination as an Alternate means for Ammoia-Nitrogen removal at a Water Reclamation Plant
… biological process upset was to occur, due to a toxic shock load or cold weather, it may result in a discharge of ammonia or total nitrogen into the receiving water body. The impact of such a discharge could have deleterious effects on aquatic life or human health. The main objective of the …
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