Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"total tau"”.
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Sex Differences in the Relationship Between Physical Activity and Cognitive Health in Ethnically Diverse Older Adults
… amyloid-beta (Aβ)40, Aβ42, neurofilament light, total tau, and pTau-181. Hippocampal and subregion volumes and dorsolateral prefrontal cortex thickness were measured. Analysis of covariance was performed to examine the interaction between PA group, sex, and ethnicity for each outcome, adjusting …
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Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment
… (AD) usually have decreased Aβ42 but increased total-tau (T-tau) and phosphorylated tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if …
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Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, …
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Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
… system. In addition to HD, this applies to human tauopathies such as Alzheimer’s Disease (AD), which involve axonal misfolding and aggregation of tau. Increased throughput assays to test larval locomotion are developed (Chapter 3) in a Drosophila larval model of tauopathy, in which locomotion …
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Digitally quantified neuropathological correlates of structural and functional imaging biomarkers in progressive supranuclear palsy
… for differential diagnosis in neurodegenerative tauopathies. However, the relationship between imaging changes and neuropathology requires more thorough validation and beyond Alzheimer’s disease. In tauopathies, tau is the key protein where specific pattern of tau aggregation and distribution can …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… of amyloidogenic insults amyloid-β (Aβ) and tau in wildtype mice, implicating a role for PLD1 in synaptic deficits. Given this background, I implemented a 12-month-old 3xTg-AD mouse model; to corroborate a pathological role for PLD1 in AD where neuropathological hallmarks such as the Aβ and …
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Mechanisms of Regulation of Tau Ires Mediated Translation
… It was previously shown that the 5’ UTR of the tau mRNA contains an IRES. In this study I show that IRES dependent translation of tau IRES is regulated at multiple levels in order to regulate the expression of the tau protein.</p> <p>Tau protein is ubiquitously expressed but is concentrated in …
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Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease
… CSF collection at the study baseline, and Aβ42, total-tau and phospho-tau were quantified. Finally, based on the AIBL neuropsychological test battery, three cognitive composites previously developed were calculated for all participants. The cognitive composites investigated were; verbal episodic …
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Study of the sensitivity of CMS to the lepton flavour violating neutrinoless tau decay tau mymymy
… will start its operation in summer 2009. The total tau lepton production cross-section for the CMS experiment, at a center-of-mass energy of 14 TeV, is about 140 µb. Assuming an integrated luminosity of 10 fb^-1 per year, which is expected to be reached in the low luminosity phase of L = …
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Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
… is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively …
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
… PAA reduced neurotoxicity (50%, p ≤ 0.0001) and total tau levels (p ≤ 0.01). Notably, PAA alone demonstrated significant neuroprotective (˃35%, p ≤ 0.0001) and anti-inflammatory effects (˃75%, p ≤ 0.0001) in both cell lines and inhibited Aβ aggregation (˃20%, p ≤ 0.001). In vivo Drosophila …
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Cerebrospinal Fluid Biomarkers in the Evaluation and Treatment of Normal Pressure Hydrocephalus
… levels of the β-amyloid 1-42 (Aβ42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of NPH patients and tried to find their clinical implications in the evaluation and treatment of NPH. PART I: A retrospective study …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… [GFAP], neurofilament light-chain [NF-L] and total-tau [T-Tau] determined via automated clinical grade ELISA and Single Molecule Array technology). Cardiopulmonary variables included mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (<i>Q</i>), peripheral oxygen …
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Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen
… cerebrospinalis Spiegel von Transthyretin, Tau-Protein sowie der beta-Amyloidpeptide 1-42 und1-40 bei 106 Patienten mit unterschiedlichen Demenzerkrankungen wie Alzheimer-Demenz, Creutzfeldt-Jakob-Krankheit, Lewy-Körperchen-Demenz, frontotemporale Demenz und Normaldruckhydrozephalus im …