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Showing 1 to 20 of 429 for “"total synthesis"”.
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Total synthesis of (-)-tantazole B. Total synthesis of (+,-)-FR900482
… challenges to the synthetic chemists. The first total synthesis and structure revision of ($-$)-tantazole B is described herein. A convergent methodology is developed and could be applied to the synthesis of the other members of oxazole/thiazoline family.(DIAGRAM, TABLE OR GRAPHIC …
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Total synthesis of neolignans.
Thesis. 1978. Ph.D.--Massachusetts Institute of Technology. Dept. of Chemistry.
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Total Synthesis of Himastatin
I. Total Synthesis of Himastatin via Bioinspired Oxidative Dimerization The concise total synthesis of (–)-himastatin via a biomimetic final-stage dimerization is described. Our approach relies on expedient preparation of a macrocyclic depsipeptide monomer via hybrid solution/solid phase peptide …
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Total Synthesis of Mangrolide A
… bacteria has jeopardized the human health. The total synthesis of the natural products plays a crucial part in modern organic chemistry. Mangrolide A was isolated from a rare marine actinomycete strain Actinoalloteichus spitensis by MacMillan and co-workers in 2013. The first part of this thesis …
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Total Synthesis of Maoecrystal V
… Diels-Alder reaction is a big challenge for our synthesis plan. The third chapter describes our solution to the core structure of Maoecrystal V. The exploration resulted in the discovery of a novel exo-glycal epoxide rearrangement. The last chapter describes the total synthesis of Maoecrystal V. …
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The Total Synthesis of Moenocinol
Made available in DSpace on 2014-12-13T20:10:40Z (GMT). No. of bitstreams: 1 7915371.pdf: 5042387 bytes, checksum: b47c306b307ce497ff3baabdd36e9200 (MD5) Previous issue date: 1979
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The Total Synthesis of Zizaene
Made available in DSpace on 2014-12-10T23:01:28Z (GMT). No. of bitstreams: 1 7310060.pdf: 6004209 bytes, checksum: 50848108f785c3f1f1205bd3d50a1af2 (MD5) Previous issue date: 1972
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Total synthesis of marine terpenoids
… Moreover, besides advancing the field of organic synthesis, marine natural products have also had an immense influence on medicinal chemistry providing new chemical leads for further development to combat life-threatening diseases. Accordingly, several promising families of marine terpenoids were …
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The total synthesis of aristolindiquinone
… (31). Second, a general synthesis, of substituted C-5 oxygenated- 1,4-naphthoquinones is applied to the synthesis of (1). The critical step in the synthesis is the reaction of the novel Diels-Alder partners, dienophile (90), synthesized from 2,6-dihydroxytoluene (56), and …
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The total synthesis of carbohydrates
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1987.
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The total synthesis of verrucarol
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1983.
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Total synthesis of ḏḻ-camptothecin.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1975
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A total synthesis of aphidicolin
A formal total synthesis of aphidicolin, an important antitumor agent, has been accomplished. Completion of this synthesis required the development of novel methodology. Virtually all of the previous syntheses of aphidicolin share a common difficulty in the construction of the C-9 and C-10 vicinal …
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The Total Synthesis of () 7-HDHA
… the high cost and limited supply of 7-HDHA. The total synthesis of 7-HDHA was attempted using four different strategies, and finally achieved in 11 steps in the longest reaction sequence, starting from commercially available (triisopropylsilyl)acetylene and 2-pentyn-1-ol. The overall yield of …
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Enantioselective Total Synthesis of the Kibdelones
… properties the kibdelones were targeted for total synthesis. Novel methods for heterocycle synthesis and biaryl bond formation were also targeted as part of the synthesis. The kibdelones contain a chlorinated isoquinolinone and stereogenically rich tetrahydroxanthone heterocycles, which make …
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Total Synthesis of Apratoxin A Analogues
… anti-cancer activity. Also, a second generation synthesis of oxazoline analogues has been developed, which shortens the overall synthetic route and eliminates late stage epimerization problems seen in the original synthesis of oxazoline apratoxin A. In addition, we have developed a reliable …
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A novel total synthesis of antillatoxin
In this thesis, the total synthesis of (4R,5R)-antillatoxin, one of the most ichthyotoxic metabolites isolated to date from cyanobacterium, Lyngbya majuscule, is presented. The synthesis proceeds from commercial available trimethylacetaldehyde and produce the molecule in an overall yield of 1.1% …
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Total synthesis of pyranonaphthoquinone natural products
… angina pectoris. Efforts toward the direct synthesis of these natural pyranonaphthoquinones forced us to develop new methodologies. During our research, a general methodology was developed to stereoselectively synthesize the common isochromanquinone skeleton. The key step in the syntheses, a …
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Total synthesis of oxaphenalenone natural products
… lactone E. Our initial efforts achieved the synthesis of corymbiferan lactone E through the use of crossed-Claisen condensation of an isochromanone substrate followed by an interesting Au(I)-mediated 6-endo-dig hydroarylation. Subsequent studies implemented closely-related synthetic …
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