Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"tonsil"”.
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Frequency and predictors of tonsil surgery
This thesis assesses the frequency of tonsil surgery and examines its predictors. Tonsil surgery is a common procedure which carries both advantages and disadvantages. The study begins with a systematic literature review of published articles which address the frequency and predictors of tonsil …
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Phenotypic and Genotypic Models of Streptococcal Colonization of the Human Tonsil
… suggesting pathogen specificity for palatine tonsil epithelium. While recent studies are advancing the premise of pathogen-host microenvironment effects on streptococcal virulence, the specific interaction between S. pyogenes and the human tonsillar surface relative to neighboring tissues …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… the establishment of KSHV infection in the human tonsil. We have identified and characterized different cytokines that influence KSHV infection; with three specific aims:</p> <ol> <li>Determine whether manipulation of cytokine signaling influences KSHV infection in tonsil lymphocytes.</li> …
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Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
… In this study, we use ex vivo infection of tonsil lymphocytes with recombinant KSHV as a model to investigate early infection events. Our main objective is to utilize multiple approaches, including molecular knockout of vIL6 from the KSHV genome, knockout of human IL-6 through CRISPR-Cas9 …
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Assessment of Tonsil-Oral-Scrubbing (TOSc) to detect PRRSV RNA in sows and application of TOSc for PRRSV dynamics in breeding herds
… sample types for sows in the US are serum and tonsil scraping. These require snaring the sows and are labor-intensive and animal welfare unfriendly to obtain (Allende et al., 2000; Horter et al., 2002). Retrieving oral fluids (OF) from individual sows under field conditions is challenging …
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KSHV Susceptibility and Transmission Within Tonsillar Specimens
… and dynamics of KSHV infection in the human tonsil to pave the way for future interventions directed at limiting person-to-person transmission of KSHV.</p> <p>To understand the contribution of host factors to KSHV susceptibility in B lymphocytes, we generated a library of 40 tonsillar …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… to understand the viral entry process of KSHV in tonsil-derived B lymphocytes. This study will particularly explore the role of KSHV glycoprotein gH and cell surface receptor DC-SIGN.</p> <p>The first aim of this project will investigate whether the cell surface receptor, DC-SIGN, is required for …
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Timing recombinant prion protein conversion as a measure of prion activity in chronic wasting disease
… reproducible, and functions on elk brain and tonsil tissues. There are indications RePLICA has the potential to titre CWD infectivity.
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To determine the incidence of brucella abortus and certain other organisms in tonsils
… Bacillus abortus of Bang could be recovered from tonsil tissue. It is obvious that normal tonsils would not be available for this study and, therefore, one was compelled to use organs which had been removed for one reason or another - "enlarged tonsils ". From the stand point of the investigation, …
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Antibacterial peptides - key players in host defense at epithelial surfaces
… CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. Similarly, these chemokines were produced by activated pharyngeal epithelial cells in vitro. CXCL9/MIG was the predominant chemokine and also the most potent in killing GAS. Epithelial recognition of GAS, or its important virulence …
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Basal narcosis: with special reference to the use of tri-bromethanol (Avertin)
… of operations on the anus and rectum, and tonsillectomy. (9) Tonsillectomy should not be performed under avertin unless a special technique is adopted. (10) Certain conditions of the patient are better treated by avertie than by other means. These are cases of thyroid disease, diabetes, …
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Pseudorabies Virus Infection of Porcine Peripheral Blood Leukocytes
… from various lymphoid tissues (e.g., lymph node, tonsil, thymus). Lymphocytes stimulated with T cell mitogens, but not B cell mitogens, were permissive to PRV infection in vitro, as evidenced by the expression of PRV antigens on the surface of these cells and by the production of low titers of …
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The role of human CD23 in lgE homeostasis & allergic disease
… responses.<br/>To test this hypothesis, purified tonsil B cells were stimulated with IL-4 and anti-CD40 to induce class switching to IgE in vitro. mCD23 was up-regulated and sCD23 accumulated in the medium prior to IgE synthesis. IL-10 and IL-21 were shown to enhance IgE synthesis by increasing …
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Clinical correlations to distinguish from milder forms of obstructive sleep apnoea syndrome using overnight oximetry to prioritize adenotonsillectomy in a low resource setting
… of this study was to assess the correlation of tonsillar size and clinical symptoms with MOS grade 3 or 4, to identify who requires overnight oximetry and who to prioritise for adenotonsillectomy. Methods: Children with suspected OSAS were recruited from the otolaryngology clinic at the Red …
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Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
… and Viral Tropism in KSHV Infection of Tonsil-Derived B Lymphocytes</p> </li> <li> <p>Validating the Proteomic Composition of KSHV Virions</p> </li> <li> <p>Establishing the Contribution of KSHV-ORF11 Tegument Protein in de novo</p> <p>Infection of B Lymphocytes.</p> </li> </ol> <p>We …
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Poultry Performance and Food Safety Impacts of Selected Organic Acids and Probiotics
… vivo</em> with broiler chicks (crop and cecal tonsil enumeration) reduced the incidence of <em>Salmonella</em> Typhimurium. In the second study, an organic acid product showed reductions in body weight loss during feed withdrawal and transportation, and meat quality improvement of broilers …
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The combined effects of purified fiber and dietary threonine on chick growth, and gut health, when infected with coccidiosis
… highest (P < 0.01) in pectin-fed birds. Cecal tonsil IFNG and mucosal scrapings IL-12 were increased (P < 0.01) in the control diet with infection. These findings suggest that both fiber source and dietary Thr concentration affected growth performance and intestinal health indices in young …
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Investigation of protein biomarkers in HIV positive and HIV negative associated DLBCL
… This study had 12 DLBCL cases and 2 human tonsil controls diagnosed from 2009- 2011. These cases were retrieved using the NHLS database. The overall age of DLBCL patients by the time they were diagnosed ranged from 18 to 73 years, with a median age of 48 years. MALDI-IMS peak detection …
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Molecular, functional and developmental analysis of B cells at discrete stages of development
… B cells that are present in peripheral blood, tonsil and spleen. Expression of CD10 on CD10+CD27+ B cells suggested that this population may be germinal centre (GC) or memory B cells and their presence in the blood may indicate they are a population of circulating GC B cells. However, further …
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Hybrid Parallel Computing Strategies for Scientific Computing Applications
… For example, a simulation of the human tonsil at the cellular level involves the computation of the motion and interaction of millions of cells over extended periods of time. Also, the simulation of Radiative Heat Transfer (RHT) effects by the Photon Monte Carlo (PMC) method is an …
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