Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"tonic pain"”.
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An analysis of the role of midbrain dopamine systems in the suppression of tonic pain
… (DA) systems plays a role in the suppression of tonic or persistent pain. For instance, earlier work has shown that substance P (SP), a tachykinin neuropeptide released during pain and stress, acting in the midbrain induces analgesia in the formalin test for tonic pain. The present thesis …
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The effects of tonic muscle pain on the sympathetic and somatic motor systems in humans
… underlying the development of chronic muscle pain in humans remain unknown. Our current understanding is principally based on experimentation in animals, which has resulted in the formulation of a multitude of theories and physiological models to postulate these mechanisms in humans. The …
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Encoding and Decoding of Pain Relief in the Human Brain
The studies in this thesis explored how pain and its relief are represented in the human brain. Pain and relief are important survival signals that motivate escape from danger and search for safety, however, they are often evaluated by subjective descriptions only. Studying how humans learn and …
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Design synthesis and biological evaluation of non-peptide neuropeptide FF ligands
… an opportunity to evaluate neuropeptide FF in a tonic pain model. In summation, selective non-peptide ligands for each neuropeptide FF receptor offer a key tool to elucidating the evolving role of neuropeptide FF and creating potentially useful therapeutics in the future.
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Temporal Dynamics of Heat Pain Sensations
The moment-to-moment fluctuations in pain-evoked sensory and emotional qualities, and how the pain experience differs between sexes are not well understood. Therefore, this thesis sought to 1) characterise the temporal profiles of the most prominent noxious heat-evoked sensations, 2) characterise …