Global ETD Search
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Showing 1 to 2 of 2 for “"tonabersat"”.
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… ocular disease. A novel connexin modulator, tonabersat, that previously reached phase II clinical trials for the treatment of migraine, has been shown to reduce the activity of neurons after cellular injury. Despite its therapeutic potential, the impact of this connexin modulator on ocular …
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
… observed. Significantly, the anti-migraine drug tonabersat decreased neuron-glial cell communication and decreased the formation of Cx26 plaques. To my knowledge, this is the first study to look at connexin expression in trigeminal ganglion under basal and inflammatory conditions. Results from my …