Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"toll-like receptors"”.
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Role of Toll-like receptors in airway inflammation
Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. Although the TLRs protect the host from …
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The role of Toll-like receptors in Parkinson's disease
… α-synuclein aggregates, and may be mediated by Toll-like receptors (TLRs). TLRs are pattern recognition receptors with the ability to detect damage-associated molecular patterns. The activation of TLRs, potentially occurring through the detection of aggregated α-synuclein, triggers the release …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… the presence of low-density lipoprotein (LDL). Toll-like receptors (TLRs) play a central role for macrophages to detect pathogens and elicit inflammatory responses.</p> <p>Data presented in this study have furthered our understanding of the different mechanisms of foam cell formation induced by …
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THE ROLE OF P24 PROTEINS IN THE ER TO GOLGI TRANSPORT OF TOLL-LIKE RECEPTORS
Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognizing conserved structural features of bacterial or viral origin and regulate the initiation of the innate immune response. TLR signaling is subjected to a dynamic and complex regulation that remains poorly understood. Our research …
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Investigations into the role of Toll-Like Receptors in the modulation of the inflammatory response during Osteoarthritis
… associated with synovitis of the fibroblast-like synoviocytes (FLS). FLS are sentinel cells that contribute to OA pathogenesis, through secretion of various catabolic and pro-inflammatory mediators, though the downstream stimuli which initiate and propagate the inflammatory pathway remain …
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Effects of Vitamin D on Expression of Toll-like Receptors of Monocytes from Patients with Behcet's Disease
… considered to play roles in the pathogenesis. Toll-like receptors (TLRs) are involved in the initiation of innate immune response in several immune mediated inflammatory disease including BD by sensing the various microorganisms and triggering the signalling pathways, causing release of …
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Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… disease severity through cytokine production. Toll-like receptors (TLRs) 2 and 9 recognize conserved molecular patterns present in bacteria, and signal through the adaptor molecule MyD88. The goal of my project is to investigate the role of TLRs 2 and 9 in the pathogenesis of HP during the …
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Determinants of innate immune responses to mycobacteria
… and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteria. This knowledge is important for designing rational strategies for vaccination against tuberculosis.
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Analysis of the role of Pellino2 in the Activation of the NLRP3 Inflammasome.
… out by a number of families of innate immune receptors, including Toll-like receptors. Toll-like receptors can respond to a diverse range of microbial signals and elicit a targeted immune response against the invading pathogen. A key regulator of inflammation is IL-1β, which can be secreted …
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Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury
… innate immunity through the engagement of Toll-Like Receptors (TLRs) by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Stimulation of TLR4 induces distinct patterns of gene expression, which not only leads to the …
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The impact of variation in the Toll-like receptor 3 gene on epizootic hemorrhagic disease in Illinois white-tailed deer (Odocoileus virginianus)
… transmitted by midges of the genus Culicoides. Toll-like receptors (TLRs) are part of the innate immune system and detect various types of pathogens upon infection. One of the Toll-like receptors, TLR3, recognizes pathogen-associated molecular patterns in dsRNA viruses, thus playing a key role …
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Identifying TRAF1 Mutations as a Key Step to Develop a Targeted Therapy for Rheumatoid Arthritis
… is a signalling adapter downstream of TNFR and Toll-like receptors (TLR), where it plays opposing roles in the activation of nuclear factor-k-B, NF-κB. Downstream of TNFRs, TRAF1 acts as a positive regulator of NF-κB, whereas downstream of TLRs, TRAF1 acts as a negative regulator of NF-κB. TRAF1 …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with the endogenous cationic antimicrobial peptide LL37, which are …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… we show that stimulation of macrophages through Toll-like receptors (TLR) disrupts the assembly of mitochondrial electron transfer chain (ETC) complexes I-V, leading to the metabolic switch by inhibiting OxPhos and activating HIF-1[alpha]-dependent glycolysis. Disassembly of ETC complexes …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
Toll-like receptors (TLRs) are crucial players in the innate immune response to microbial invaders. There have been reported that keratinocyte TLRs represent the first barrier against exogenous pathogens in human skin. Recently, it was reported that melanocytes not only function melanin synthesis …
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Clinical approaches for understanding the expression levels of pattern recognition receptors in otitis media with effusion
… this study we evaluated the expression levels of Toll-like receptors (TLRs) -2, -4, -5, -9, and nucleotidebinding oligomerization domain-containing proteins (NODs) -1 and -2, all of which are related to bacterial infection in pediatric patients with otitis media with effusion (OME). METHODS: The …
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Characterizing the function of human toll-like receptor 10
Toll-like Receptors (TLRs) are important constituents of the immune response, capable of both protecting the host from danger and inciting harm from within. In this Thesis, I present evidence that the last human orphan toll-like receptor, TLR10, has a unique function that differs from its other …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… may sense alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit different responses are not …
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Combinatorial lipid-like materials for intracellular delivery of small RNAs that activate innate antiviral immune responses and adjuvant vaccines
… immune cells occurs through pattern recognition receptors, which have evolved to respond to RNA viruses, such as the Toll-like receptors (TLR) 7 and 8 located in the endosome of dendritic cells. Tailoring the multiple functions of RNA for a desired clinical application will require novel systems …
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