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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 65 for “"toll-like receptor 4"”.

  1. Role of Toll-Like Receptor 4 in Pathophysiology of Hypertension

    Dange, Rahul BabulalBiomedical and Veterinary Medical Sciences - Comparative Biomedical Sciences2017

    … regimens. Very recently, role of toll-like receptors (TLRs), particularly TLR4 in pathogenesis of several inflammatory conditions including cardiovascular diseases are becoming evident. However, the functional im-portance of the brain TLR4 and its interaction with other molecules …

    lsu-thes Repository record

  2. Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium

    Song, Jeongmin2008

    … unrecognized functions for this innate immune receptor.</p>

    duke Repository record

  3. Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages

    Zhang, YanUniversity of Missouri--Kansas City2017

    … evidence suggests that pattern recognition receptors of the innate immune system such as the toll-like receptors (TLRs) are involved. In the present study, we tested the central hypothesis that TLR4 is the link between reactive oxygen/nitrogen species (RONS), oxidative stress and …

    umkc Repository record

  4. Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins

    Kelley, StacyUniversity of Illinois at Urbana-Champaign2013

    … pattern recognition complex comprised of Toll-like receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is …

    uiuc Repository record

  5. The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection

    Albertyn, ZulfahDepartment of Medicine2012

    … in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3.

    cape-town Repository record

  6. Expression of functional active Toll like receptor 4 in normal and adenomatous pituitary cells

    Tichomirova, MariaLudwig-Maximilians-Universität

    … wurde erstmals die Expression und Bedeutung des Toll-like Rezeptors 4 (Tlr4) in normalen und adenomatösen epithelialen Hypophysenzellen untersucht. Tlr4 ist der Rezeptor für bakterielle Lipopolysaccharide und ist daher an der Induktion der angeborenen Immunantwort bei Infektions- oder …

    lmu-germany Repository record

  7. The role of Toll-like Receptor 4 in the Modulation in Skeletal Muscle Metabolism

    Wu, YaruVirginia Tech2011

    Toll-like receptor 4 (TLR4) is a transmembrane receptor, which upon activation by lipopolysaccharide (LPS) from Gram-negative bacteria, plays an important role in the induction of the innate immune response. Our lab has previously demonstrated that activation of TLR4 in skeletal muscle results in …

    vt Repository record

  8. Adiponectin and Toll-Like Receptor 4: Important Adipocyte Modulators of Systemic Glucose and Lipid Metabolism

    Tao, Caroline2017

    … to increased adipose tissue inflammation. Toll-like receptor 4 is an important mediator of inflammatory response found abundantly on the cell surface of adipocytes. In this study, using an adipocyte- specific deletion, we demonstrated a dichotomous effect of Toll-like receptor 4 on adipose …

    utswmed Repository record

  9. Investigating the role of toll-like receptor 4 in myocardial ischaemic-preconditioning and ischaemic-reperfusion injury

    Lee, Samuel Man2018

    … whether the suppression of upstream inflammatory receptors is more effective in attenuating myocardial inflammation during ischaemic-reperfusion injury. This thesis investigates the role of toll-like receptor 4 (TLR4), an immunosurveillance receptor, in both myocardial ischaemic-reperfusion injury …

    adelaide Repository record

  10. The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity

    McMillan, Ryan P.Virginia Tech2009

    … in concert with chronic low-grade inflammation. Toll-like receptors (TLR) are transmembrane receptors that play an important role in innate immunity and the induction of inflammatory responses. Our laboratory has observed that TLR4 expression is elevated in the skeletal muscle of obese humans and …

    vt Repository record

  11. The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection

    Abel, BrainDivision of Immunology2002

    … Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of an aerosol Mtb infection. The following questions were posed: Are the PRR-disrupted animals more susceptible to M.tuberculosis infection? What role do these …

    cape-town Repository record

  12. The Electrochemistry of Ferrocenyl-thiolate Self-Assembled Monolayers for use in a Toll-like Receptor 4-based sensor

    Singh, RaunakScience2021

    … is imperative for biodefense applications. Unlike radiological and chemical warfare agents, sophisticated detection systems have not yet been designed for immediate sensing of biological agents. Development of field-deployable biosensors is a response to fulfill this gap, specifically, the …

    calgary Repository record

  13. The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation

    Ali, Mostafa M.Virginia Tech2017

    Toll like receptor-4 (TLR4) is a transmembrane inflammatory receptor expressed ubiquitously on the cell surface of immune cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle …

    vt Repository record

  14. Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.

    Mattke, Jordan Dean, 1991-Baylor University.2024

    … mass lost during type 1 or type 3c diabetes. Toll-like receptor 4, a pattern recognition receptor found on various immune, endothelial, and epithelial cells, can respond to both endogenous and exogenous ligands resulting in enhanced cytokine and chemokine production as well as immune …

    baylor Repository record

  15. Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts

    Alsousi, AsmaaUniversity of Missouri -- Kansas City2018

    … Evidence suggests that oxidant-induced Toll-like receptor 4 (TLR4) activation plays a significant role in initiating “sterile” inflammation. Here, we investigate for the first time the role of RATM-induced oxidant stress in the molecular mechanism of the pathogenesis of RA. Potassium …

    umkc Repository record

  16. Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production

    Okada, YoichiroKyoto University2018

    kyoto Repository record

  17. Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation

    Kowalski, Elizabeth AshleyVirginia Tech2017

    … circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external …

    vt Repository record

  18. Studies of hyperphosphorylated tau aggregation and cytotoxicity

    Meng, JonathanUniversity of Cambridge2022

    … efficiently disrupt membrane bilayers and induce Toll-like receptor 4-dependent responses in human macrophages. We also found that non-phosphorylated tau could polymerize into amorphous, cytotoxic aggregates when induced by hyperphosphorylated tau in situ, having similar structural and functional …

    cambridge Repository record

  19. Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines

    Park, Hyun J2011

    … Further, knowing mBD2’s link with CC chemokine receptor 6 (CCR6) and Toll-like receptor 4 (TLR4) we note that this enhanced class I T cell expansion is CCR6 independent but TLR4 dependent. With anti-tumor responses desired, we demonstrate in tumor protection experiments with mice, compelling …

    uthsc Repository record

  20. Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages

    Smith, Tyler Joseph

    … numerous pro-inflammatory mediators through Toll-like receptor 4 (TLR4) binding to lipopolysaccharide (LPS). IL-10 acts on these cells through the induced expression of genes that inhibit expression of select TLR-induced pro-inflammatory genes. Our understanding of the mechanisms by which …

    mo-state Repository record

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