Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"toll-like receptor 3"”.
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The impact of variation in the Toll-like receptor 3 gene on epizootic hemorrhagic disease in Illinois white-tailed deer (Odocoileus virginianus)
… transmitted by midges of the genus Culicoides. Toll-like receptors (TLRs) are part of the innate immune system and detect various types of pathogens upon infection. One of the Toll-like receptors, TLR3, recognizes pathogen-associated molecular patterns in dsRNA viruses, thus playing a key role …
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Functional characterization of human and chicken TLR3
Toll-like receptor 3 (TLR3) is a critical component of the innate immune system, responsible for detecting viral double-stranded RNA (dsRNA) and initiating downstream signaling pathways, including activation of the transcription factor NF-κB. While TLR3 function has been extensively characterized …
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… mechanisms of the innate immune response, Toll-like receptor 3 (TLR3) recognizes viral dsRNA and signals subsequent production of type-I interferon. The TLR3:interferon signaling cascades contains a kinase complex composed of two kinases and a scaffold protein, NAK-associated protein 1 …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
… TNF-α, and IFN-γ, as well as an agonist of toll-like receptor 3. HSP90 release was not found to result from cellular increases in HSP90AA1 gene or HSP90 protein expression levels. Rather, cell stress and ensuing cytotoxicity mediated by c-Jun N-terminal kinase (JNK) appeared to play a role …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… signaling components. Characterization of Toll-like receptor 3 (TLR3) in HCV infection indicated that the NS3/4A protease cleaves TRIF, an essential adaptor protein required for TLR3 signaling. However the TLR3 pathway was not found to be essential for generating the intracellular antiviral …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… agents. Critical to this safeguard is the receptor-mediated detection of pathogens. Pathogen recognition then initiates a variety of signaling cascades that lead to the modulation of genes orchestrating an immune response. Toll-like receptor 3 (TLR3), a transmembrane receptor found in …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
… signaling components. Characterization of Toll-like receptor 3 (TLR3) in HCV infection indicated that the NS3/4A protease cleaves TRIF, an essential adaptor protein required for TLR3 signaling. However the TLR3 pathway was not found to be essential for generating the intracellular antiviral …
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Evasion of RIG-I/MDA5 and TLR3-mediated innate immunity by hepatitis A virus
… of several families of pattern recognition receptors (PRRs), their roles in the innate immune system and how they are regulated by the invading pathogens have been the subjects of extensive research. Cellular helicases RIG-I and MDA5, and Toll-like receptor 3 (TLR3) are PRRs that detect …
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Innate immunity in Zika Virus infection and neurogenesis deficits
… pregnancy. ZIKV-associated microcephaly is most likely due to the high susceptibility of neural stem/progenitor cells (NS/PCs), the origin of the brain, to ZIKV. Microglia are the first and major innate immune defenders of the brain. They arise exclusively from the progenitor cells in the …
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Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal Pneumonia Virus of Mice.
… mediated by a novel formulation composed of the toll-like receptor 3 agonist poly I:C, an innate defense regulator peptide and a polyphosphazene (i.e. P-I-P) was first assessed in healthy adult Balb/c mice. Subsequently, the protective potential of P-I-P was further investigated in the context of …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… how innate immune sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were measured in primary human hepatocytes (PHH) and hepatocyte lines harboring functional or …
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Host cell signaling in response to RSV infection
… that retinoic acid-inducible gene I (RIG-I) and Toll like receptor 3 (TLR3) play distinct roles in mediating RSV-induced innate immune responses. Short interfering RNA (siRNA)-mediated RIG-I \"knockdown\" significantly inhibited the translocation of nuclear factor-kappa B (NF-kappa B) and …
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Role of dendritic cells in response to cytokine gene adjuvants
… were detected. Both subpopulations express Toll like receptor 3 (TLR3) and TLR9, whereas SIRPa" ALDC uniquely express TLR4 (+/- CD14). Gene-gun vaccination with pGM-CSF resulted in increased cytokine transcripts in both ALDC subpopulations and an upregulation of surface MHC class Ila, CD lb, …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… also shown that TRIM56 forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues 621-750, and augments TLR3-mediated interferon (IFN) induction and establishment of an antiviral state. Yet, TRIM56’s antiviral spectrum and the precise underlying mechanisms by …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
With current standard-of-care treatments, approximately 20% of stage II and 36% of stage III colon cancer (CC) patients will experience disease relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of …