Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"tofacitinib"”.
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the selective JAK3 inhibitor GSK192 on IL-2 control of effector CD8+ cytotoxic T cells (CTL). On the basis of these preliminary data, a detailed analysis of the effect of tofacitinib on effector …
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Investigation of novel topical therapeutics for chronic rhinosinusitis
… acid, Zoono GermFree24 and Nasodine; tofacitinib, a Janus kinase inhibitor, for management of the dysregulated immune response; and tetracaine with oxymetazoline to facilitate postoperative debridement and optimise surgical outcomes. All antimicrobials tested had varying degrees of …
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Microneedle array patches for skin hyperthermia and enhanced intradermal drug delivery
… to enhance the intradermal delivery of tofacitinib citrate, a drug for which clinical trials provide strong evidence for its effectiveness against inflammatory skin conditions. However, oral administration is not ideal due to reported side effects. Skin deposition studies showed that …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… (10), anakinra (3), abatacept (1), and tofacitinib (1). The vast majority of patients had an excellent response and were in low disease activity or remission at their last available visit. Adverse events included severe infection (4), tuberculosis (TB) (2), mild infection (4), severe …
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Regulation of cytokine and chemokine production in macrophages
… in response to LPS. Another JAK inhibitor, Tofacitinib, also blocked the sustained transcription of IL-10 and led to elevated secretion of pro-inflammatory cytokines in response to LPS.<br/>The IFNb-mediated feedback loop also regulated the transcription of another mediator in the …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… JAK1-biased inhibition with upadacitinib or tofacitinib did not produce a statistically significant sensitization phenotype under the conditions tested, whereas inhibitors with substantial JAK2 activity, including fedratinib and ruxolitinib, consistently increased cochlear vulnerability to …