Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"tobramycin"”.
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Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
… study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was used when the …
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Acinetobacter baumannii : an evaluation of five susceptibility test methods to detect tobramycin resistance in an epidemiologically related cluster
… At several hospitals within Cape Town, tobramycin and colistin remain frequently the only therapeutic options. The Vitek2 automated susceptibility testing (AST) is used in the clinical laboratory to determine selected susceptibility profiles. The suspicion of a possible AST-related …
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The location, expression and regulation of three antibiotic resistance genes in acinetobacter
… aspirate; it is resistant to gentamicin, tobramycin, netilmicin, streptomycin, chloramphenicol and suphamethoxazole. This study examines the nature of the resistance to gentamicin, tobramycin and chloramphenicol at three levels: the biochemical mechanism of resistance, the location of the …
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… to multiple antibiotics including ciprofloxacin, tobramycin, tetracycline, and gentamicin. The mucoid variant, P. aeruginosa PDO300 was also sensitized by GM-CSF to tobramycin in the presence of alginate lyase. In addition, GM-CSF sensitized the biofilm cells of P. aeruginosa PAO1 and PDO300 to …
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Biochemical and antibiogram characteristics of certain enterobacteriaceae
… Proteus and Escherichia coli. New antibiotics (tobramycin, amikacin and cefamandole) are also added to the antibiogram.
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Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
… für das MS2-Hüllprotein oder das Aminoglykosid Tobramycin in das Prä-mRNA Substrat eingefügt, die eine Markierung der RNA für Affinitätsselektionen bereitstellten. Die erste Prozedur kombiniert Dichtegradientenzentrifugation und Affinitätsselektion mittels Maltose-bindendem Protein (fusioniert …
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Identification of new therapeutic compounds against carbapenemase-producing Klebsiella pneumoniae using a novel agar-based high-throughput microarray compound screening approach
… sulfate, kanamycin sulphate, G418 sulfate, and tobramycin), seven (polymyxin B sulfate, colistin sulfate, gentamicin sulfate, kanamycin sulphate, G418 sulfate, tobramycin, neomycin sulfate), and five (kanamycin sulphate, neomycin sulfate, gentamicin sulfate, G418 sulfate, tobramycin) drugs, …
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Synergistic Effects of Monoculture Biofilm Dispersion and Antibiotic Treatment
… with antibiotics. Antibiotics selected were tobramycin and nitrofurantoin due to their clinical use against urinary tract infections. Both potential dispersal agents showed the most effect when used to treat P. aeruginosa biofilms cultured in Luria-Bertani broth (LB). There was no increased …
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Perfil de resistência aos antimicrobianos frente à pseudomonas aeruginosa isoladas de afecções oftálmicas em diversas espécies: revisão sistemática
… to aminoglycosides (amikacin, gentamicin and tobramycin), to fluoroquinolones (levofloxacin, ciprofloxacin, nofloxacin and gatifloxacin) and to Imipenem. In the isolates were observed resistance of the 82,9% to chloramphenicol, proving not to be effective against Pseudomonas aeruginosa. This …
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Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics
… P.aeruginosa was subjected to the action of tobramycin, amikacin and colistin under various environmental factors. The results of the in vitro analysis showed that, from among the three antibiotics used, amikacin was the antibiotic where resistance was most readily developed. From these …
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Επίδραση της χρήσης αντιβιοτικών στις μέσες και υψηλές ακοομετρικές συχνότητες
… amikacin (4 άτομα), gentamycin (47 άτομα) και tobramycin (2 άτομα) και οι οποίοι δεν είχαν κανένα προηγούμενο πρόβλημα που να αφορά το όργανο της ακοής. Για τη μελέτη αυτή κρίθηκε απαραίτητη προϋπόθεση ένα ελάχιστο 4 ακουογραμμάτων. Από τις πρώτες μετρήσεις που έγιναν, έχοντας κάνει ήδη …
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Novel small molecules for modulation of bacterial signaling pathways
… of some potent QS inhibitory compounds with tobramycin also showed two-three fold enhanced P. aeruginosa biofilm inhibitory effect compared to single tobramycin treatment. These findings highlight the potential usefulness of synthesized compounds in this project with non-violent modes of …
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Studies on the outer membrane of Pseudomonas aeruginosa and associated resistance properties
… became more resistant to BKC. Resistance to tobramycin in strain OO14 was initially high, but fell as cells were adapted to BKC, this coincided with a quantitative reduction of plasmid DNA in the cells.
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A multiplexed microfluidic platform for antibiotic susceptibility testing
… to antibiotics such as amikacin and tobramycin increases in co-cultures. I illustrate the advantages of using microfluidics over conventional methods for AST for precise determination of antibiotic dosing regimen, which encompass a significant potential to address the issue of …
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Application of population pharmacokinetic-pharmacodynamic modelling evaluate and optimise aminoglycoside therapy in patients with cystic fibrosis
… using data from The Hague that comprised tobramycin concentration measurements from 165 patients who received 415 courses of therapy. The results of this analysis indicated good performance of the model in predicting pharmacokinetic parameters and concentrations in another group of …
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Investigating the Role of the Antimicrobial Peptide TTO-53 in the Disruption of Pseudomonas aeruginosa Biofilm
… while decreasing the efficacy of Tobramycin. This study revealed that an hour-long exposure to TTO-53 does not impact P. aeruginosa quorum sensing pathways and the combination treatment of TTO-53 has a synergistic effect with some antibiotics while inhibiting others.
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Population dynamics of bacterial persistence
… in a Staphylococcus aureus population upon tobramycin treatment. In summary, we identify several roles of bacterial persistence, such as help in spatial expansion, development of multidrug tolerance and emergence of antibiotic resistance. Our study provides a theoretical perspective on the …
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Effects of substrate stiffness on bacterial biofilm formation
… antimicrobials, such as ofloxacin, ampicillin, tobramycin and lysozyme, than the cells attached on soft substrates. The cell tracking results revealed that the E. coli cells on stiff surfaces were more mobile than those on soft surfaces, suggesting that the cells attached on soft surfaces may …
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In-vitro- und In-vivo-Untersuchungen zum Einfluss der Keimkontamination auf den Funktionsverlust resorbierbarer chirurgischer Nahtmaterialien
… durch eine selektive Darmdekontamination mittels Tobramycin, Polymyxin, Vancomycin und Metronidazol die colorectale Mikroflora verändert und deren Keimzahl messbar reduziert werden kann. Dadurch konnte die Resorptionszeit der resorbierbaren Nahtmaterialien verlängert werden, was sich unmittelbar …
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Electrochemical Control of Bacterial Persister Cells
… cells with 70 μA/cm<sup>2</sup> DC and 1.5 μg/mL tobramycin together using SS 304 electrodes. The same level of DC was also found to be cidal to biofilm associated persister cells of <em>P. aeruginosa</em> PAO1. Based on this discovery, the electrophysiological properties of <em>P. aeruginosa</em> …
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