Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"titin"”.
-
Smooth muscle titin in embryo implantation and angiogenesis
Das Muskelprotein Titin ist mit einem Molekulargewicht von bis zu 3700 kDa das größte bekannte Polypeptid. Es ist nach Aktin und Myosin das dritthäufigste Protein im quergestreiften Muskel. Titin integriert in die Z-Scheibe und die M-Bande und überspannt damit das halbe Sarkomer. Es formt ein …
-
PATHOGENIC MECHANISMS OF TRUNCATED TITIN IN DILATED CARDIOMYOPATHY
… gene encoding the essential sarcomeric protein titin (TTNtv) have long been known to cause dilated cardiomyopathy (DCM) and, recently, peripartum cardiomyopathy (PPCM). How these genetic variations lead to the hypocontractility that is characteristic of DCM and PPCM has remained controversial …
-
Modulation of Cardiac Titin Stiffness in Physiological and Pathophysiological States
The giant sarcomeric protein titin spans the length of the half sarcomere and contains an I-band spanning region that functions as a molecular spring that develops passive force during diastole. Titin stiffness is modulated both by isoform switching and post-translational modifications including …
-
A Proposed Mechanism for Enhanced Titin-Based Force during Ca2+-activation
… following active stretch may be provided by the titin protein in the sarcomere, which becomes stiffer during Ca2+-activation. This thesis explores the mechanisms by which titin force is enhanced in actively stretched sarcomeres. Known to stiffen in the presence of Ca2+, the first study quantifies …
-
Protein interaction studies on the titin A150 domain using proximity-dependent biotinylation
Titin is an enormous protein that spans over 1 µm in the sarcomere, making it the largest protein in the human body. A single missense variant within the titin A150 domain, also called FN3 119, is sufficient to cause a dominant myopathy known as Hereditary Myopathy with Early Respiratory Failure …
-
Tensile properties of ovine skeletal muscle fibres: Thermal denaturation and selective removal of titin.
… three aspects of these events; sarcomere length, titin degradation and heat. Each of these factors was experimentally manipulated in vitro and the effect on the stiffness of single muscle fibres was measured. A technique was developed to apply strain to the fibre while recording the corresponding …
-
Development of an experimental system to determine the contribution of titin and collagen to passive stiffness of myocardium
… mechanics, are alterations in intracellular titin and extracellular collagen matrix. Titin is a giant extensible protein, the third filament of striated muscle after actin and myosin, which provides elasticity to passive sarcomeres. The aim of this study is to develop an efficient …
-
Computational Investigations of Cellular Functions: Three Cases on Membrane Morphogenesis, Organization and Assembly of a Multi-Protein Complex, and the Molecular Origin of Muscle Elasticity
Titin is a mechanical protein that protects muscle from overstretching by producing a restoring force when a muscle fiber is extended beyond its normal length. Force spectroscopy studies have shown that titin exhibits several regimes of elasticity. Disordered segments bring about a soft, entropic …
-
Computational Studies on the Mechanical Properties of Muscle and Blood Clot Elasticity
… basis of elasticity for muscle from the protein titin and for blood clots from the protein fibrinogen. These investigations utilize free dynamics MD to verify experimentally observed conformations of proteins, SMD to probe their response to mechanical forces, and adaptive biasing force (ABF) …
-
Charakterisierung der Bindung des Stressproteins Alpha-B-Crystallin an kardiale Myofibrillen unter Ischämie
… Linie Komponenten der I-Bande, d.h. Aktin und Titin in Betracht zu ziehen. Z-Scheiben Proteine wie a-Actinin treten dagegen in den Hintergrund. Um Anhaltspunkte über die Bindungsstärke des Stressproteins aB-Crystallin an kardiale Myofibrillen unter Ischämie zu erhalten, wurden …
-
Towards the rational design of mechanical proteins
… Of the many mechanically important proteins titin and titin-like proteins are important on many levels. From a physiological understanding of the way mechanical strength is propagated from sarcomere to muscle tissue, to a theoretical understanding of the molecular mechanisms contributing to …
-
Computational investigations of cellular functions: Three cases on membrane morphogenesis, organization and assembly of a multi-protein complex, and the molecular origin of muscle elasticity
… curvature in the photosynthetic membrane. Titin is a mechanical protein that protects muscle from overstretching by producing a restoring force when a muscle fiber is extended beyond its normal length. Force spectroscopy studies have shown that titin exhibits several regimes of elasticity. …
-
Running Economy: Improvements In Physiological Efficiency Attained Through Changes In Muscle Structural Morphology
… RE, lactate-threshold, biomechanics, plus titin-protein isoform identification via gel electrophoresis from vastus lateralis biopsies. Post-testing revealed faster running performance for the plyometrics group without concomitant improvements in fitness data. While RE was not altered, …
-
Running Economy: Improvements In Physiological Efficiency Attained Through Changes In Muscle Structural Morphology
… RE, lactate-threshold, biomechanics, plus titin-protein isoform identification via gel electrophoresis from vastus lateralis biopsies. Post-testing revealed faster running performance for the plyometrics group without concomitant improvements in fitness data. While RE was not altered, …
-
The effect of calcium activated protease (CAF) and cathepsin D on bovine muscle myofibrils under varying conditions of pH and temperature
… myofibrils showed CAF digestion had degraded titin and, at least partly, tropomyosin, and troponins T and I. A trio of bands in the 30,000-dalton region appeared in the gels of the sedimented myofibrils. CAF treatment caused a significant increase in myofibril fragmentation;Lowered incubation …
-
Enforced Large-Scale Motions in Proteins
… exit from bacteriorhodopsin, unraveling of titin and fibronectin domains, and rotation of the central stalk within an ATP synthase F1 unit. SMD methods employed include linear constant-velocity extension, multiple-trial segmented path creation, and torque application to enforce angular …
-
Charakterisierung der kardialen Funktion des Stressproteins alpha-B-Crystallin am isolierten Papillarmuskel der Maus
… Translokation vom Zytosol an das elastische Titin-Filamentsystem lassen eine protektive Rolle von alpha-B-Crystallin unter Stressbedingungen vermuten. Ziel der vorliegenden Arbeit war es, eine eventuelle kardioprotektive Funktion von alphaB-Crystallin durch die Charakterisierung …
-
Molecular Dynamics Simulation of Force-Induced Protein Domain Unfolding
… a new component of elasticity of muscle protein titin. Also has been suggested from the SMD simulation is a molecular recognition switch, a novel signaling mechanism, in extracellular matrix protein fibronectin.
-
Identifying biological pathomechanisms of TTN-affected myopathies using RNA-Sequencing data
… of 364 exons (363 coding) and encodes for titin, the largest protein in nature. Pathogenic TTN variants result in a wide spectrum of skeletal muscle and cardiac disorders known as Titinopathies. These differ in inheritance patterns, onset age, disease course and severity. The biological …
-
PCP and conformational motifs: applications in predicting mechanical strength, allergenicity of proteins and vaccine design
… (Ig) domains of the muscle protein titin by introducing motifs from mechanically strong Ig domains to weak Ig domains. The Atomic Force Microscope (AFM) results showed the enhanced mechanical strength for several of the engineered proteins. I developed a scoring method to evaluate …
Page 1 of 2