Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"tissue-specific gene expression"”.
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Codon Usage Biases Differ Between Tissues and Can Confer Tissue-Specific Gene Expression in Drosophila
… usage bias is a fundamental aspect of the genetic code. For many years synonymous mutations to a coding sequence were considered to be functionally “silent.” We now appreciate that is not the case and that synonymous codon choice can have drastic implications for gene expression and protein …
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Integrating Epigenetic Priors For Improving Computational Identification of Transcription Factor Binding Sites
… and histone modifications play critical roles in tissue-specific gene expression. Identifying binding sites is key in understanding the regulatory interactions of gene expression. Nave computational approaches uses solely DNA sequence data to construct models known as Position Weight Matrices. …
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Large-scale inference and imputation for multi-tissue gene expression
Integrating molecular information across tissues and cell types is essential for understanding the coordinated biological mechanisms that drive disease and characterise homoeostasis. Effective multi-tissue omics integration promises a system-wide view of human physiology, with potential to shed …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… to the 24-hour daily cycle and regulates tissue-specific gene expression and downstream physiology. The central pacemaker located in the hypothalamic suprachiasmatic nuclei (SCN) synchronizes the peripheral clocks in different tissues. This dissertation aims to uncover specific circadian …
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Genetics of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii)
… between 2015 and 2020, I provide the first genetic and functional comparisons of these two transmissible Tasmanian devil cancer lineages. My results suggest that both DFT1 and DFT2 emerged recently and independently in different devil subpopulations, yet from similar Schwann cell-related …
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Informatics Strategies for Alzheimer’s Disease Research Through Analyzing Genetics and Neuroimaging Data
Alzheimer’s disease (AD) is a complex neurodegenerative disorder influenced by intricate interactions among genetic, molecular, and clinical factors. This dissertation advances AD research by employing informatics strategies within the Genomics, Molecular Multiomics, Biomarkers, and Outcomes (GMBO) …
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DNA Methylation: Methods and Analyses
… used to quality control data. These tools focus specifically on data-driven aspects of quality control that are often overlooked and can cause problems during downstream analysis. Comparison of these tools to other popular methods demonstrate that the tools I created are effective in decreasing …
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Monitoring the Effects of the Oncogenic S250F Mutation on the Intrinsically Disordered C-terminal of FoxA1
… and open condensed chromatin and thus establish tissue-specific gene expression. FoxA1 plays a pivotal role for the correct development of various mesoderm derived tissues during embryogenesis and modulates the transcriptional activity of nuclear hormone receptors during adulthood. FoxA1 contains …
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Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
… transcription factor that regulates tissue-specific gene expression in the kidney, liver, and other organs. Humans with heterozygous mutations of HNF-1β develop maturity-onset diabetes of the young type 5 (MODY5) associated with cystic abnormalities of the kidney. A yeast two-hybrid …
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… transcription factor that regulates tissue-specific gene expression in the liver, kidney, pancreas, and other epithelial organs. During kidney development, HNF-1Beta is expressed in renal collecting ducts and all segments of the nephron. Mutation of HNF-1Beta causes maturity-onset …
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Exploiting gene expression and protein data for predicting remote homology and tissue specificity
… acknowledged in the bioinformatics community. Specifically, this work makes three novel contributions based on the systematic analysis of publicly archived data of protein sequences, three dimensional structures, gene expression and functional annotations: (a) remote homology detection based on …
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Understanding Gene Regulation In Development And Differentiation Using Single Cell Multi-Omics
… regulation is a major determinant of tissue-specific gene expression during development. My thesis research leverages powerful single-cell approaches to address this fundamental question in two developmental systems, C. elegans embryogenesis and mouse embryonic hematopoiesis. I have …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
During tissues development multipotent progenitor cells establish tissue-specific gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of …
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Bioinformatic and biological analysis of DNA methylation in the human genome
Epigenetics is the study of DNA related information heritable through meiosis and mitosis that does not include the DNA code itself. DNA methylation is currently the most studied epigenetic mark. It is a part of the inactivation of the X chromosome, defense against transposable elements and the …
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Endogenous short interfering RNAs that silence chalcone synthase result in pigment pattern formation on soybean seed coats
… to duplications of chalcone synthase (CHS) genes leading to production of CHS siRNAs which in turn degrade CHS mRNAs resulting in yellow seed coats (Tuteja et al., 2009 and Vodkin et al., 2012). However, it was not known if the same phenomenon applied to the yellow and pigmented regions …