Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 481 for “"tissue-specific"”.
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Tissue-specific adaptations of cell types
… blocks of life, forming the vast diversity of tissues and organisms in Nature. Across these, common cellular morphologies and functions have been identified. High-throughput, multifactorial profiling of cells has grown exponentially in recent years with the advent of single-cell RNA-sequencing …
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Characterizing the maize Xanthomonas vasicola pv. Vasculorum pathosystem: tissue-specific lifestyles and natural variation in tissue-specific resistance
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Tissue- specific DNA methylation profiles in newborns
… chronic diseases in adulthood. Derangements in tissue-specific epigenetic programming of fetal and placental tissues are a suggested mechanism of which DNA methylation is best understood. DNA methylation profiles in human tissue are mostly performed in DNA from white blood cells. The objective …
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Tissue specific genetic regulation of Interleukin 6
… of SNP G-174C in humans, in vivo in different tissues. Varicose vein surgery patients donated adipose tissue, skeletal muscle, vein and blood samples. Patients were genotyped for SNP G-174C. A new pre-mRNA assay was developed, using gel electrophoresis, restriction digest and fluorescence …
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Sequence motifs predictive of tissue-specific skipping
… regulating gene expression. Motifs that regulate tissue-specific alternative splicing have been identified by groups studying small sets of genes. We introduce a tissue-specific skipping score for skipped exons using exon-exon junction microarray data. We compare these exons with known …
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Mechanisms of tissue-specific regeneration in planarians
… establish and maintain the sizes of myriad tissues and organs in tight proportion to one another is a fundamental question of developmental biology. Planarian flatworms regenerate from diverse injuries, in each case precisely restoring body parts to their appropriate proportions. Underlying …
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Studying Tissue Specific Diversity of Splicing Regulator Muscleblind
… mRNA transcript composition for various types of tissue, and has been implicated in myotonic dystrophy. The mbl gene is subject to alternative splicing in Drosophila, leading to multiple isoforms, and has several paralogs in humans. Mbl proteins vary significantly in length, although the …
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Tissue-specific classification of alternatively spliced human exons
… Cruz (UCSC) genome browser were analyzed for tissue-specific skipping. Expressed sequence tags (ESTs) were aligned to exons and their tissue of origin and histology were identified. ACEs were also identified as a subset of the skipped exons. About 18% of the exons were identified as …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… the site of this inductive response in rat tissue sections. It was found that lung macrophages were markedly induced to produce ACE, as was ACE in seminiferous tubules. ACE induction was also noted in the expected sites of renal tubular epithelium and glomerular tissue. Interestingly, ACE …
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Identifying and characterizing genes that regulate vascular tissue-specific functions
Vascular tissues provide both the mechanical support to the plant body and the conducting cells for the transport of water, mineral solutes, hormones and other signaling molecules, amino acids, and sugars. To identify genes that may regulate vascular tissue-specific functions, we isolated xylem, …
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
… We developed hepatocyte- and macrophage-specific ABCA1 knockout mice (HSKO and MSKO, respectively) and crossed them into the atherogenic low density lipoprotein receptor knockout (LDLrKO) background to study their roles in atherogenesis.
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
… role, each ECM molecule contributes a context-specific signal that influences cellular fate and behavior. Among these behaviors, cellular migration provides an essential function in developing tissues, wound healing, and cancer cell metastasis. Using two glandular organs, the normal salivary …
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Engineering of an anti-PAI-1 antibody with tissue specific activation
… the tumour microenvironment which has a very specific protease expression signature. My aim is to investigate the use of pro-antibodies for tissue targeting. By using anti-PAI-1 pro-antibodies to specifically target the kidney for the treatment of chronic kidney disease to minimise observed …
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The germline- and tissue-specific effects of endogenous point-mutant p53
… Syndrome (LFS). They developed allele- specific tumor spectra that were distinct from p53+/- mice and that better reflect the broad spectrum of tumors found in LFS patients. Dominant effects that varied by allele and function were observed in primary cells derived from these mice. In …
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The autoregulatory and tissue-specific activation of gene expression by estrogen receptor
A single, transient dose of estradiol-17$\beta$ is sufficient to elicit the permanent induction of hepatic estrogen receptor mRNA, which is induced 18-fold, from 0.13 molecules/cell to 2.4 molecules/cell, and then remains fully induced for at least 125 days. In primary liver cultures, extremely low …
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Precision Delivery of Multi-Scale Payloads to Tissue-Specific Targets in Plants
… the precise deployment of payloads in plants. Specifically, the thesis designs a novel silk-based biomaterial and fabricates a microneedle-like device capable of delivering a variety of payloads ranging from small molecules to large proteins into specific loci of various plant tissues. …
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The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… SNX27 is variably expressed in different tissues, its role specifically in the intestines and the development of intestinal disorders remains to be unexplored. Epithelial barrier integrity, regulated by junction proteins, is critical for the maintenance of intestinal tissue homeostasis. …
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Characterizing Tissue-Specific actinodin1 Reporter Expression in Danio rerio Fins Throughout Development and Regeneration
… pectoral and median fin fold. The presence of tissue-specific cis-acting regulatory elements were found within the 2 kilobase pair genomic region (2P) located upstream of and1’s first untranslated exon by performing analyses of the expression of a fluorescent reporter (EGFP) placed under the …
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