Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"tissue-resident memory"”.
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
<p>Tissue-resident memory T-cells (T<sub>RM</sub>) provide frontline defense against viral diseases and can contribute to anti-tumor immunity; however, aside from the necessity of TGF-β, little is known regarding cues for T<sub>RM</sub> differentiation. Oxygen tension is an environmental cue that …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… CD39+CD8+T cells often co-express the tissue resident memory marker CD103 and display an exhausted tissue resident memory T cell phenotype that shows cytotoxicity against neoplastic cells. CD39 acts in concert with CD73 to generate adenosine and thereby promote immunosuppression in the …
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way their B cell receptors bind antigen and generate antibodies that provide protection against infections. Due to their de novo formation and less stringent assembly, it is unknown whether tertiary …
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Development of a novel co-vaccination approach for pneumococcal and influenza infections
… pneumococcal-specific effector Th17 and Th1 memory cells, promoted development of CD4+ tissue-resident memory cells, and enhanced pneumococcus-specific antibody responses. In addition, this combination approach was shown to elicit significant protection against lethal influenza challenge, as …
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An alternative diagnostic method using microneedles for sampling the immune system in situ
… major populations of immune cells reside within tissues, these invasively-obtained body fluid samples are, at best, indirect indicators of the status of the immune system. Direct tissue sampling through biopsies is difficult to incorporate into long-term, repetitive, longitudinal immune …
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Adaptive Immunity: From Autoimmune Diseases to Neuroinflammation
… pathogens and to facilitate healing of damaged tissue. However, this process must be controlled to limit immunopathology. Cell-intrinsic effects of inhibitory and signaling molecules are known to maintain quiescence and prevent effector differentiation and inflammation. Moreover, specific …
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T Cell Responsiveness Through the Ages: Functional Diversity of Age-Dependent Antiviral Responses
… repair scores. This was reflected within tissue resident memory (TRM) CD8 T cells, activated regulatory CD4 T cells (Tregs), and activated AREG+ γδ T cells. The repair profile was then applied across publicly available datasets spanning ages, tissue types, etiologies, and severities, and …