Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"tissue structure"”.
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Diffusion MRI of complex tissue structure
… provides an exquisitely sensitive probe of tissue microstructure. Owing to the microscopic length scale of diffusion in biological tissues, diffusion imaging can reveal histological architecture irresolvable by conventional magnetic resonance imaging methods. However, diffusion imaging …
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Volumetric reconstruction of tissue structure from two-dimensional microscopy images
Cell morphology of tissue is naturally three-dimensional. Most current methods for tissue analysis use two dimensional histological images of the tissue samples, restricting the analysis to 2D. Existing approaches do not provide essential three-dimensional information such as cell volume, shape and …
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Biological and Biomechanical Effects of Direct Perturbation of Tissue Structure in the Cirrhotic Liver
… of cirrhosis that can exert greater influence on tissue architecture. This thesis explores three innovative treatment strategies, each aimed at directly perturbing tissue structure through a distinct mechanism. First, we investigate microinjury perturbation using a fractional laser. This work …
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Multimodal intravital imaging of tissue structure and cell dynamics in skin using integrated optical coherence and multiphoton microscopy
… skin, including macroscopic and microscopic structure, microvasculature, collagen networks, single cells and single cell nuclei. In addition to multimodal imaging, technical challenges associated with long-term tracking of the same skin site in vivo are addressed through the development of a …
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Characterising fat tissue structure and function in response to hypoxia in grey seals, an animal model of extreme fat deposition and mobilisation, using novel <i>in vivo</i> and <i>in vitro</i> approaches
… In humans, excess fat accumulation leads to tissue remodelling, potential hypoxia, chronic inflammation and oxidative stress. Although these processes are strongly interrelated, evidence suggest hypoxia, as result of limited vascularity or impaired diffusion, is the underlying trigger. How …
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Fundamental representations of regions and interactions in spatial transcriptomics
… spatial coordination that gives rise to the tissue architectures underlying both health and disease. Spatial transcriptomics technologies offer a unique window into this coordination by simultaneously capturing the spatial and molecular identities of individual cells, providing unprecedented …
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Imaging and spectroscopy of tissue-like phantoms using photon density waves: Theory and experiments
… and absorbing properties of biological tissue would allow for the non-invasive and non-ionizing imaging of tissue structure and the monitoring of physiology. Until recently, such characterization of thick, highly scattering biological tissues using visible and near infrared light has …
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Spectroscopic Optical Coherence Tomography: Mechanisms, Methodology, and Applications
… dyes and nano-particles, are used in labeling tissue structure and enhancing contrast. Scattering mode SOCT has the advantage of localized analysis, but its results are often difficult to interpret due to various complicating factors such as the beam effect and the multiscatterer effect. …
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Early diagnosis of cancer using light scattering spectroscopy
… developed for quantitative characterization of tissue morphology as well as in vivo detection and diagnosis of the diseases associated with alteration of normal tissue structure such as precancerous and early cancerous transformations in various epithelia. LSS employs a wavelength dependent …
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The biomechanical properties of the human vocal fold.
… larynx. Within the larynx there is a specialist tissue structure known as the vocal folds, which under muscular control captures energy within the airflow and transfers it to a dynamic phenomena, analogous to a static fluid wave, known as the mucosal wave. This mucosal wave causes the vocal folds …
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Coordinated Control of Liver-Specific Genes in Cultured Cells from Mice and Rats
… hepatocytes. In contrast, slices of liver tissue exposed to the same culture conditions for 24 hours maintained high rates of liver-specific transcription. These and other experiments demonstrate that: 1) maximum transcription of many liver-specific mRNAs depends on the maintenance of the …
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Experimental design and analysis for high-parameter spatial omics
… progress from bulk data, averaged across entire tissues or organisms, to single-cell measurements, which enable exploration of the vast diversity between individual cells, to a new frontier, spatial omics, which enables rich molecular measurements of single cells in their native tissue context. …
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Investigating Murine Uterine Tissue Dynamics: Biomechanical and Histological Perspectives on Postpartum Involution and Scar-Induced Remodeling
… the procedure, the uterus and abdominal tissue are carefully sutured to support postpartum recovery, leading to uterine scarring at the incision site<sup>1,2</sup>. Understanding the relationship between uterine scar integrity, postpartum involution, and the biomechanics of uterine tissue …
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Effect of melt method on thoracolumbar connective tissue
… from low back pain (LBP). Altered connective tissue structure has been identified in adults with chronic LBP. Numerous novel treatments are being developed targeting the connective tissue and nervous system to relieve people from LBP. One such self-care treatment is the MELT method. The …
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The Role Of Adult Stem Cells And Tumor Necrosis Factor In Peripheral Neuropathy
… to stromal support provided by ADSCs. The ultrastructure of the nerve was not significantly improved, indicating that the threshold of functional motor improvement can be met through alternative means. In the second study, we developed a process to identify highly-connected genes in a model of …
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The evaluation of fibrin tissue adhesive for skin closure following eyelid surgery
The use of fibrin tissue adhesives in clinical practice has grown over the past 10 years, and there has been increased use of adhesives in different surgical subspecialties. Conventional suture closure of periorbital tissues is effective however may result in complications, which has led to the …
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Advances in Optical Coherence Tomography and Microscopy for endoscopic applications and functional neuroimaging
… cross-sectional images of subsurface internal tissue structure in situ and in real time, without the need to remove and process specimens. Previous studies have suggested that OCT holds great potential for use in laparoscopic and endoscopic applications to detect early stage neoplastic …
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Development of a three-dimensional camera based on subsampled optical coherence tomography (OCT)
… allows label-free, three-dimensional imaging of tissue structure. Current implementations of OCT can either image over long depth ranges at slow imaging speeds, or over limited depth ranges at high speeds. Here, we describe a new OCT paradigm that supports simultaneous high speed and long depth …
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Tissue spectroscopic characterization based on fluorescence, second harmonic generation, and reflected light
… often requires a histological analysis of tissues. Histology analysis compares the microscopic structure of a tissue specimen with an image database containing known physiological and pathological tissue structures. Three new microscopy technologies are developed to complement histology …
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Developing platforms to investigate mechanotransduction during wound healing
Wound healing in adult skin tissue lacks the ability to recapitulate uninjured tissue structure-function, forming instead fibrotic tissue with limited functionality. The extracellular matrix regulates forces on a cell- and tissue-specific level. Fibronectin, a mechanically regulated extracellular …
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