Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"tissue sampling"”.
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Tissue sampling array for tumor marker profiling
… instrument for the preparation of excised frozen tissue from prostate cancer tumors in patients for conformal mapping of the sampling points to the local tissue geometry. This instrument was designed specifically for use on frozen samples that have been archived and the work involves solving …
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Evaluating metabolism in human renal cancer using novel surgical models
… vivo*. Secondly, by developing a novel *in situ* tissue sampling method, I demonstrated the profound impact of ischaemia, a variable commonly associated with conventional tissue sampling methods, on the metabolic characterisation of RCC. Lastly, in order to develop more clinically relevant models …
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Necrobiome Succession in Muscle Tissue as a Potential Indicator of Postmortem Interval
… through the use of buccal swab and muscle tissue sampling from the arm (deltoid) and thigh (vastus lateralis). The use of muscle tissue samples is a novel means to study bacterial succession during human decomposition. Utilization of 16s rRNA sequencing provided information used to assess …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
… approaches, primarily relying on MRI and tissue biopsies, have limitations. MRI sensitivity is limited, and tissue sampling is invasive and may not accurately reflect tumor heterogeneity. Thus, the need for a non- invasive strategy to complement MRI and tissue profiling is critical to …
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Validating FTA card skin swabs as a source of DNA from wild amphibians
… unprotected skin which lacks dead keratinised tissue, current standard techniques for DNA sampling of endangered amphibians are either destructive (sacrifice of entire animals) or can involve distinctly invasive techniques such as tissue sampling based on toe or tail tip clips. The present MSc …
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Genexpressionsanalysen zur Charakterisierung primärer Mammatumoren im neoadjuvanten Setting
… or time (before or after treatment) of the tissue sampling. The dominant role of estrogen and steroid biosynthesis in breast cancer is one conclusion of the present study. The complex mechanisms influencing the disease require further studies concerning additional molecular levels (genome, …
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Corn tissue nutrient response related to soil health and fertility
… for high-yielding corn production. While soil sampling for fertility testing is the generally accepted standard for making these decisions, this alone may poorly represent plant nutrient availability. Another tool used for managing plant nutrient health is tissue sampling and analysis. This …
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Patterns of protein expression in tissues of the killifish, Fundulus heteroclitus and Fundulus grandis
… observation that the responses are both tissue- and enzyme-specific. Chapter 3 studies the effect of tissue storage on protein profile of tissues of F. grandis. The technique of one dimensional gel electrophoresis (1D-SDS-PAGE) was used to assess the effects of tissue sampling, flash …
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Statistical methods for genetics and genomics studies
… of the lability of RNA, steps involved in tissue sampling, RNA purification, and RNA storage are known to potentially lead to the degradation of RNAs, therefore, assessment of RNA quality is essential. Existing methods for estimating the quality of RNA on microarray either suffer from …
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Development and application of an antibody-based protein microarray to assess stress in grizzly bears (Ursus arctos)
… rapid manner with small samples of grizzly bear tissue. Sampling from four regions in the foothills of the Rocky Mountains in Alberta resulted in the capture of 133 bears. During the developmental phase, proteins involved with mitochondrial function were found, using two dimensional gel …
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Effect of application of fluidized bed combustion residue to reclaimed mine pastures on forage yield, composition, animal performance and mineral status
… intervals and all animals were sacrificed for tissue sampling at the end of the 114-d trial. Amendment with FBCR or limestone increased soil pH (P < .05) above control levels. Forage yield and steer gain were not significantly affected by treatment. Forage samples collected during the trial …
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Computer simulation to guide choice of breeding strategies for maker-aided multiple trait integration in maize
… homozygosity as well as seed chipping and tissue sampling approaches to facilitate genotyping. With self-pollination approaches, 2 generations of selfing rather than 1 for Trait Fixation (i.e. ‘F2 enrichment’ as per Bonnett et al. (2005)) were utilized to eliminate bottlenecking due to …
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Effects of Corn (Zea mays L.) Stover Removal and Leaching on Soil Test and Whole Plant K Levels in Corn and K Fertilization/High-Input Treatments on Soybean Using Site-Specific Management to Increase Soybean (Glycine max) Production in South Dakota
… were recorded between the initial and final sampling periods. While corn grain yields were affected by removing corn biomass, exchangeable and solution K+ levels were relatively unaffected by stover removal. Potassium fertilizer has the potential to mitigate yield decreases associated with …
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Selection and competition of somatic mutations in normal epithelia
… understand the journey from healthy to cancerous tissue, it is important to study the accumulation and spread of mutations in pre- cancerous normal tissues. Recent studies have shown that apparently normal epithelium contains a high burden of mutations in cancer-associated genes. This thesis …
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An alternative diagnostic method using microneedles for sampling the immune system in situ
… major populations of immune cells reside within tissues, these invasively-obtained body fluid samples are, at best, indirect indicators of the status of the immune system. Direct tissue sampling through biopsies is difficult to incorporate into long-term, repetitive, longitudinal immune …
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Nitrogen and Sulfur Management in Soybean and Edamame Production in the Mid-Atlantic Coastal Plain
… source responses were site-specific. Sulfur leaf tissue concentrations were directly related to S rate (S concentration = 0.004S rate + 2.103). Nutrient uptake responses to S fertility indicate the potential for S yield responses in the future when soils become S depleted and contain less …
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Double volumetric navigators for real-time simultaneous shim and motion measurement and correction in Glycogen Chemical Exchange Saturation Transfer (GlycoCEST) MRI
… concentrations in vivo still largely relies on tissue sampling methods via needle biopsy. However, muscle biopsies are invasive and limit the frequency of measurements and the number of sites that can be assessed. Non-invasive methods for quantifying glycogen in vivo are therefore desirable in …
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Clinical and biological validation of hyperpolarised MRI of prostate cancer
… confirmation limited by the potential for sampling error and procedure-associated complications. Therefore, improving the diagnostic performance of standard-of-care MRI and its specificity for aggressive disease could reduce the requirement for tissue sampling and associated patient …