Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 127 for “"tissue repair"”.
-
Tissue repair in lung disorders
The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main …
-
Periostin-like-factor in tissue repair and remodeling
… present in adults. PLF is up regulated in adult tissues when they are exposed to stress or insult. We have previously shown that PLF is up regulated in heart when they are mechanically overloaded and in lung when exposed to cigarette smoke. Similarly in bone, PLF is highly up regulated in …
-
Design of Biomaterials toward Endogenous Skeletal Tissue Repair
<p>Repair of skeletal tissues remains a significant challenge in patient care as there is high incidence of impaired fracture healing as well as irreversible cartilage degeneration following joint injury. To improve the repair outcome, recent advancements have been made in regenerative medicine …
-
The influence of arginine upon growth and tissue repair
Growth is a fundamental property of living matter. It depends upon the reception of an appropriate stimulus by a potentially reactive cell, under conditions which permit this to respond.
-
Property determination of biomedical polymer scaffolds for cervical tissue repair
… of applying these scaffolds in the future for tissue engineered UC. Methods of evaluation of this study were permeability testing, stress-relaxation test, dynamic mechanical analysis (DMA) as well as scanning electron microscopy (SEM). The Z1A1 and Z3A1 samples were tested with and without …
-
Self Assembling Bioactive Materials for Cell Adhesion in Tissue Repair
… materials that have the potential to modify tissue engineering scaffolds through self assembly, generating multiple layers that deliver bioactivity. Diblock biomaterials containing cholesteryl moieties and oligomers of lactic acid units were found to form single crystals when precipitated …
-
A Design, Development, and Evaluation of Bio-Patch for Myocardial Tissue Repair
… concern of human health issue. The structural repair and functional recovery of injured hearts is a major challenge in the clinical setting. Preclinical studies over last 10 years have demonstrated the potential of using stem cells to treat IHD, but the efficacy of this therapy is jeopardized …
-
Metabolic Coordination of Stem Cell Fate Controls Tumor Initiation and Tissue Repair
<p>Tissue stem cells balance fate decisions of self-renewal and differentiation to maintain homeostasis over the lifetime of an organism, as well as to repair tissues upon injury and wounding. Disrupting the balance between self-renewal and differentiation results in pathology: excessive …
-
Design, Production and Characterisation of Anisotropic Collagen Scaffolds for Cardiac Tissue Repair
… there has been limited success achieving this in tissue engineering scaffolds. Unidirectional ice-templating has been established in prior work and collagen structures with anisotropic porosity can be created via control of ice nucleation and growth. This thesis aims to advance knowledge using …
-
Innate immunity in defence against infection and tissue repair of the urinary tract
… of chronic kidney disease. A complex network of tissue-resident immune cells exists throughout the urinary tract that are vital for initiating and propagating local immune responses, however our understanding of their nature and function remains incomplete. In this thesis, we aim to understand …
-
The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
… lungs. ECM dysregulation can cause aberrant lung tissue repair and remodelling. Lung fibroblasts and airway smooth muscle cells (ASMCs) are the major producers and regulators of the ECM and therefore play an important role in lung tissue repair and remodelling. The aim of this thesis was to …
-
FABRICATION AND CHARACTERIZATION OF CELL-LADEN 3D PRINTED HYBRID SCAFFOLDS FOR ESOPHAGEAL TISSUE REPAIR
Tissue engineering (TE) provides promising results in restoring defected or diseased esophageal tissue functions. Nevertheless, existing fabrications are hardly used to achieve a suitable scaffold for esophageal TE. In this study, a hybrid porous scaffold consisting a layer of electrohydrodynamic …
-
PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
… where TP508 and its derivatives accelerated repair of radiation induced DNA double strand breaks. To test in vivo activity, murine models for mitigation of ionizing radiation using outbred male CD-1 mice were used. These studies demonstrated that injection of only two of the TP508 derivatives …
-
Delivery of hiPSC Derived Cardiomyocytes via an Injectable Nanofibrous Gelatin Polyurethane Composite Scaffold for Heart Tissue Repair
… enhance the mechanical compliance with cardiac tissue and accelerate degradation of the polyurethane scaffold, a newly formulated composite nanofibrous scaffold containing 55% of gelatin and 45% of the polyurethane composite was generated using a two-spinneret co-electrospinning method. Acclular …
-
An injectable gelatin-based conjugate incorporating EGF promotes tissue repair and functional recovery after spinal cord injury in a rat model
… the root cause - degeneration and loss of neural tissue. The overall goal of this pre-clinical work was to evaluate a novel gelatin-based conjugate (gelatin-hydroxyphenyl propionic acid; Gtn-HPA) capable of undergoing covalent cross-linking in vivo after being injected as a liquid. Gtn-HPA …
-
Syndecan-4 regulates cell-surface trafficking and biological activity of transglutaminase-2
… TG2 modulates cell adhesion, proliferation and tissue repair. Under continuous cell insult higher expression and elevated extracellular trafficking of TG2 contribute to the pathogenesis of tissue scarring. TG2 is known to have affinity for heparin, and in a previous study cell-surface heparan …
-
The Soft Tissues in Osteoarthritis and Arthroplasty of the Hip
… might be contributing factors. Posterior soft tissue repair was suggested to reduce the dislocation rate and decrease the volume of postoperative fluid in the THA hip. THA patients with or without posterior soft tissue repair were analyzed. To evaluate postoperative capsular distension, …
-
Purification and characterization of bioactive peptides from bovine colostrum and evaluation of their role in tissue repair and regeneration [Purificazione e caratterizzazione di peptidi bioattivi dal colostro bovino e valutazione del loro ruolo nella riparazione e rigenerazione dei tessuti]
Introduzione: Il colostro bovino è definito come la prima secrezione lattifera prodotta dalla ghiandola mammaria delle mucche dopo la nascita ed è ricco di vari composti bioattivi che forniscono numerosi benefici per la salute degli esseri umani. Negli ultimi anni, il colostro bovino ha …
Page 1 of 7