Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"tissue plasminogen activator (tPA)"”.
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Synthesis and expression of the Erythrina trypsin/tissue plasminogen activator (tPA) inhibitor encoding-gene : genetic dissection to correlate the interaction of Erythrina and Soybean trypsin inhibitors with tPA
… to trypsin, it inhibits chymotrypsin and tissue plasminogen activator (tPA). ETI was previously sequenced and its crystal structure determined from which it could be seen that ETI has good homology to soybean trypsin inhibitor (STI). However, STI does not inhibit tPA. From the …
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Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre
… disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to assess the short-termoutcomes and safety of …
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Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
… of several proteolytic components including, tissue plasminogen activator (tPA), plasminogen, procathepsin B and tenascin C. Targeting the Nterminus of AnxA2 with a competitive hexapeptide that prevents the binding of proteolytic components inhibited the AnxA2-mediated neovascular responses. …
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Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
… to as fetal alcohol syndrome (FAS). Since tissue plasminogen activator (tPA) has been implicated in mediating excitotoxic neurodegeneration we subjected neonatal WT and tPA<sup>-/-</sup> to an acute ethanol paradigm that serves as a model of FAS. We observed persistent upregulation of tPA …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
… which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… treatment options for ischemic stroke, with tissue plasminogen activator (tPA) being the only effective medication and a narrow administration window, which is also accompanied with the high incidence of ischemic stroke in HIV-1 infected individuals. Therefore, it is critical to explore an …
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Targeting autophagy for improving stem cell function in brain repair
… following stroke. Aside from intravenous (i.v.) tissue plasminogen activator (tPA), there is no current cure or treatment for stroke. As a result, this study aims to target autophagy in neural stem cells to identify if stem cell functionality can be improved in in vivo models of ischaemic brain …
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
… fibrinolytic (ie blood clot dissolving) system, tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) were not affected by exposure to venous levels of shear stress (4 dynes/cm$\sp2$). However, at arterial shear stresses of 15 and 25 dynes/cm$\sp2$, the tPA …
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Investigation of the role of neuroserpin in neurite outgrowth and learning and memory
… in the nervous system and inhibits the protease tissue plasminogen activator (tPA). Neuroserpin has been shown to play a role in neurite outgrowth but con icting results have been reported. Neuroserpin has also been proposed to play a role in learning and memory but direct evidence for such a …
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
… are limited to the administration of</p> <p>tissue plasminogen activator (tPA) and/or endovascular therapy, administered within</p> <p>a limited time window. However, cell-based therapies such as mesenchymal stromal</p> <p>cells (MSCs) have increasingly shown great promise for ischemic stroke …
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The Impact of Hyperglycemia on Post-Reperfusion Outcomes in Patients with Hyperacute Ischemic Stroke
… including intravenous thrombolysis with tissue plasminogen activator (tPA) and mechanical thrombectomy, has significantly improved functional outcomes for ischemic stroke patients. However, hyperglycemia at the time of hospital arrival is associated with worse outcomes, including …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… gaining popularity. I found that two biomarkers, tissue plasminogen activator (tPA) antigen and tissue inhibitor of metalloproteinase-4 (TIMP-4), measured in a blood sample taken a mean of 3 days after AMI, were independent predictors of adverse remodelling. These findings are novel, provide …