Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"tissue physiology"”.
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Optical Imaging Of Tissue Physiology With Exogenous Contrast Agents
… emitting exogenous contrast agents in living tissue. The first set of experiments concurrently measured cerebral blood flow and bothintravascular- and extravascular-tissue oxygen concentration in a rat brain during functional activation; the new instrumentation needed to collect this …
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Role of GPS2 in the regulation and maintenance of adipose tissue physiology and function under metabolic stress and obesity
… that result from dysfunctions of white adipose tissue (WAT). As an endocrine organ, WAT is often possessed of a high degree of plasticity, capable of matching the metabolic conditions of which it is presented and responsible for maintaining an overall homeostatic energy balance. However, a …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… energy storage and expenditure in the adipose tissue, a system collectively known as the "brain-fat axis". Neuropeptide Y (NPY) is orexigenic and promotes adipogenesis in both birds and mammals, although mechanisms in adipose tissue are unclear. The first objective was thus to evaluate effects …
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Multi-parametric photoacoustic/ultrasound localization (PAUL) imaging and its applications
… and functional information for comprehensive tissue characterization. This thesis introduces a dual-modal photoacoustic and ultrasound localization (PAUL) imaging platform that integrates super-resolution ultrasound localization (UL) with photoacoustic (PA) imaging to enable multiparametric …
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Multinuclear and Mononuclear Polyploidy in the Drosophila Hindgut and Heart
<p>A fundamental question of biology is how tissues are organized. Tissues can be composed of many small cells or comparatively fewer large cells that add nuclear content to facilitate tissue growth. The cells can be separate, discrete units or interconnected collectives. The nuclear composition of …
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Collagen-mimetic peptides for diagnosis and analysis
… in the human body, is an essential scaffold for tissue development, regulation, and homeostasis. As a major structural component of the extracellular matrix, collagen is not static. Rather, it is highly diverse and dynamic, actively participating in tissue physiology. Collagen can be a …
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Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… Y (NPY)-mediated regulation of adipose tissue physiology in broiler chickens during the early post-hatch period. A high-carbohydrate (HC), high-fat (HF) or high-protein (HP) diet was fed to broiler chicks in all experiments and various facets of physiology were evaluated at day 4 …
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Dinitroxides in Rapid Scan Electron Paramagnetic Resonance Imaging
<p>Local tissue physiology is an important parameter in understanding disease behavior. Rapid Scan (RS) electron paramagnetic resonance (EPR) offers a unique, non-invasive tool for investigation of these so-called microenvironments through EPR Imaging (EPRI). Research into advancement of EPRI falls …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… effective therapeutics. Promising approaches in tissue engineering and stem cell biology have significantly improved the structural and functional maturity of the engineered heart tissue derived from human induced pluripotent stem cells, which can be served as a complementary method to …
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Time-domain diffuse correlation spectroscopy: instrument prototype, preliminary measurements, and theoretical modeling
… then be used to infer details of the underlying tissue physiology. Diffuse correlation spectroscopy (DCS) is a complimentary optical technique that relies on long-coherence laser light, also in the near-infrared range, to measure dynamical properties of a medium { in the biomedical context, blood …
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Molecular and cellular mechanisms of energy homeostasis in birds
Hypothalamus and adipose tissue are essential central and peripheral sites regulating energy homeostasis. Disruption of energy homeostasis can lead to diseases like anorexia and obesity in humans and reduced productivity in animals. Therefore, integrating knowledge in hypothalamic appetite …
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Modeling Stem Cell Population Dynamics
… of complicated cell mechanisms and tissue physiology. Indeed, even single cell or small tissue samples are complex dynamic systems that adapt to environmental challenges in space and time which is poorly understood. Mathematical models and computer simulations can explain and uncover …
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The Effects of Chronic Nitrite Exposure on Tissue Morphology and Physiology in Xiphophorus couchianus
… water nitrite concentrations can affect fish physiology. Moreover, there is a lack of current knowledge on how nitrite effects maternal health and, consequently, embryo health and development. Therefore, we used the live-bearing fish species Xiphophorus couchianus as a model organism to better …
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Optical Cerebral Blood Flow Monitoring of Mice to Men
… both employ near-infrared light to investigate tissue physiology millimeters to centimeters below the tissue surface. DOS is a static technique that analyzes multispectral tissue-scattered light intensity signals with a photon diffusion approach (Chapter 2) or a Modified Beer-Lambert law …
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Structure-functionality relationship of collagen scaffolds for tissue engineering
<p>Tissue engineering is a promising technology that enables scientists to create artificial organs or replace damaged tissues using animal cells and other components. For successful tissue regeneration, many factors should be taken into account, however, three components are most crucial: cell, …
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A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
… in vitro models of the human gut, among other tissues, that more faithfully emulate the native tissue structure and function, including organotypic cultures and bioengineered tissues. In parallel, organs-on-chips technology has emerged as a promising alternative to traditional approaches, and …
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A microphysiological system for studying barrier health of live tissues in real time
… elusive due to the lack of tools to maintain tissue's physiological environment while elucidating cellular functions under various stimuli ex vivo. This thesis presents a microphysiological system capable of recording real-time barrier permeability of mouse gut tissues in a realistic …