Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"tissue morphogenesis"”.
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The role of cell division during tissue morphogenesis
<p>During embryonic tissue morphogenesis, cell division increases both the number of cells and cellular diversity. This is often regulated by the positioning of daughter cells post-mitosis. The goal of this dissertation research is to determine the mechanisms that place daughter cells, and how this …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
Morphogenesis is defined as the change of body shape over time, the understanding of which is one of the central questions of developmental biology. To achieve proper overall organ and body shape, morphogenetic movements have to be precisely controlled during development. I have used both genetic …
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Controlled local delivery of RNA : regulating tissue morphogenesis
… relevant timescales for local delivery into tissues. We describe the development of the first high-throughput approach for LbL assembly and screening and its use to identify lead candidate film architectures for RNA delivery. We then apply these findings to treat dysregulation in two distinct …
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Forces Generated by Cell Intercalculation Tow Epidermal Sheets in Mammalian Tissue Morphogenesis
<p>Underlying the dramatic tissue movements of development—the bending, folding, squeezing, pushing, pulling, mass movements, and individual movements—are processes of cell migration. Throughout our lives, cell migration plays a role in the maintenance and regeneration of our tissues, and even in …
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The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis
During embryonic development, epithelial tissues grow and become sculpted into complex shapes through highly coordinated cell behaviors, such as cell shape change and cell division. Both processes involve contractile forces generated from distinctly organized actomyosin networks. How cells …
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The characterisation of Pax3 expressant cells in adult peripheral nerve
Pax3 has numerous integral functions in embryonic tissue morphogenesis while knowledge of its complex function in cells of adult tissue continues to unfold. Across a variety of adult tissue lineages, the role of Pax3 is principally linked to maintenance of the tissue’s resident stem and progenitor …
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Molecular organization of the actin cortex in apical constriction and epithelial folding
… and myosin generate contractile forces to change tissue and cell shape. These shape changes are essential for many biological functions, ranging from muscle contraction to tissue morphogenesis in development. While the spatial organization and composition of the actin and myosin contractile force …
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The Neurotrophic Influence on Craniofacial Development Subsequent to in Utero Unilateral Transection of the Trigeminal(V) Nerve
… in the regulation of cellular differentiation, tissue morphogenesis, subsequent development and growth, and maintenance of the craniofacial complex. This research is believed to be the first time that such a procedure has been attempted on a mammalian fetus. Each animal was clinically evaluated …
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The interplay of matrix rigidity and mechanical stretching for the development of artificial skin
Tissue engineering and regenerative medicine provides the possibility for generating organs in laboratorial settings as an off-the-shelf-technology that can provide an alternative therapeutic pathway for transplantations and replace non-functional organs. Many engineered tissues have been attempted …
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Cellular Morphodynamics Reveals Divergent Mechanisms of Gastrulation in Insects
… cellular rearrangements collectively result in tissue morphogenesis. One fundamental morphogenetic process is tissue internalisation, of which the earliest occurrence drives mesoderm gastrulation in a wide variety of organisms. In both the fly Drosophila melanogaster and the beetle Tribolium …
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The Role of Cell Division Orientation during Zebrafish Early Development
… is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual contribution of stereotypical cell division …
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The Impact of pH on the Structure and Function of Neural Cadherin
… is involved in diverse processes including tissue morphogenesis, excitatory synapse formation and dynamics, and metastasis of cancer. During neurotransmission and tumorigenesis, fluctuations in extracellular pH occur, causing tissue acidosis with associated physiological consequences. …
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Engineered microenvironments for studying liver progenitor differentiation
… progenitor specification process and subsequent tissue morphogenesis. However, the complexity of these signaling pathways and their currently undefined interactions with other microenvironmental factors, including extracellular matrix (ECM), remain barriers to complete mechanistic understanding. …
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Cell Polarity Establishment in the Budding Yeast Saccharomyces Cerevisiae
… of cell polarity is central to cell motility, tissue morphogenesis, and cell proliferation. A highly conserved group of polarity regulators is responsible for organizing a wide variety of polarized morphologies. One of the most widely expressed polarity regulators is the Rho-type GTPase Cdc42. …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… plays an important role in differentiation and tissue morphogenesis as well as cancer progression. However, the role of TGF-β in cancer is complicate. TGF-β has primarily been recognized as tumor suppressor, because it can directly inhibit cell proliferation of normal and premalignant epithelial …
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… and drug screening. This is especially true for tissues that are difficult to study due to tissue sensitivity and limited regenerative capacity, such as the heart. Previous work in stem cell-derived cardiac tissue has exploited how we can engineer biologically functional heart tissue by providing …
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Analysis of embryonic development in Tribolium castaneum using a versatile live fluorescent labelling technique
… our knowledge of embryonic patterning and morphogenesis beyond the Drosophila paradigm. In contrast to Drosophila, most insect embryos exhibit the short or intermediate-germ type and become enveloped by extensive extraembryonic membranes. The genetic basis of these processes has been the …
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Lysine Specific Demethylase-1 and the Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development
… genes, including those required for eye and wing tissue morphogenesis. A temperature sensitive mutation in one of the core subunits, SNR1 (SNF5/Ini1/SMARC B1), results in reproducible wing patterning phenotypes that can be enhanced and suppressed by extragenic mutations. SNR1 functions as a …
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Specification And Function Of Early Hair Follicle Stem Cells
… of early SCs, hair follicle and sebaceous gland morphogenesis is blocked and epidermal wound repair is compromised. To begin dissecting the molecular pathways that are required for early SC specification, a microarray screen was conducted to identify genes regulated by Sox9 during in vivo SC …
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The role of PTPRF and PTPRK in regulating cell adhesion
… (pTyr) levels and playing essential roles in tissue morphogenesis. Plasma membrane RPTPs are well positioned to sense external environmental cues, such as cell-cell contact, and transmit signals via their intracellular domains (ICDs). Among these, Protein tyrosine phosphatase receptor type K …
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