Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"tissue models"”.
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Microfluidic Platform for Vascularized Tissue Models
… designed to support 3D vascularized tissue models for microphysiological systems. The platform delivers pneumatic pressure and vacuum signals to drive fluid flow and pressure on tissue culture devices with integrated pumps and back-pressure regulators. The mechanical performance of the pumps …
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Development of advanced 3D tissue models and O2 imaging methodologies
… and the various applications for these in vitro tissues combined with novel O2 and temperature nanoparticle probes. Here a new method for O2 sensing was introduced, measuring extracellular oxygenation using solid state polystyrene scaffold (AlvetexTM) impregnated with the phosphorescent dye …
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Advancing techniques for engineered tissue models of the bone marrow
… cells ex vivo are constantly evolving; however, models that capture the hypoxic nature and heterogeneity of natural tissues such as the bone marrow are difficult to develop. Oxygen tension is known to play a role in several physiological processes, such as wound healing and angiogenesis. Though …
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Design of 3D bioengineered cardiac tissue models for advanced in vitro testing
L'abstract è presente nell'allegato / the abstract is in the attachment
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Space radiation-induced bystander signaling in 2D and 3D skin tissue models
… different cell types cultured within 2D and 3D tissue architectures. 2D bystander signaling was investigated using a transwell insert system in which normal human fibroblasts (A) and keratinocytes (K) were irradiated with 1 GeV/n protons or iron ions at the NASA Space Radiation Laboratory using …
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Ultrasonic Characterization of Three Animal Mammary Tumors From Three-Dimensional Acoustic Tissue Models
… investigated how three-dimensional (3D) tissue models can be used to improve ultrasonic tissue characterization (UTC) techniques. Anatomic sites in tissue responsible for ultrasonic scattering are unknown, which limits the potential applications of ultrasound for tumor diagnosis. Accurate …
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Sustainable biomedical practices in designing and testing new therapies through solvent free drug nanoencapsulation and tissue models
L'abstract è presente nell'allegato / the abstract is in the attachment
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Development of Multibody Soft Tissue Models and Their Tuning to Experimental Data: With a Focus in the Canine Meniscus
… to capture the flexible behavior of biological tissues inside of a rigid body mechanics software. To accomplish this, segmented multibody models of canine menisci were created and the parameters governing the interaction of adjacent segments were tuned to create an overall physiological meniscus …
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Characterization of molecular dynamic changes in tissue model systems using Fourier transform infrared spectroscopic imaging
… and exogenous molecular dynamic changes in tissue model systems often provide essential information to improve our understanding of these systems. For instance, the endogenous changes within tumor tissues induced by interactions between tumor and stroma are not only indications of tumor …
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Models for Testing Contemporary Ultrasound Systems
… These new developments motivate demand for new tissue models. The work discussed in this thesis presents different tissue models for these areas of contemporary ultrasound systems development.<br/>Acoustic test objects, known as phantoms, are the most widely used basis for testing medical …
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Modeling the Heterogeneous Brain Tumor Microenvironment to Analyze Mechanisms of Vascular Development and Chemoresistance
… goal of this research is to generate in vitro models of the heterogeneous brain tumor microenvironment, with a focus on vascular dynamics, to probe the impact of microenvironmental cues on tumor progression and to integrate the tumor models with highly sensitive analytical tools to characterize …
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Design of a test apparatus to study a proposed dynamic tissue puncture model
… evaluated in order to study a proposed dynamic tissue puncture model. The test apparatuses were designed to improve existing experiments used previously to experimentally verify tissue models. These models are incomplete due to the small range of velocities tested (up to 250 mm/s) and because …
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Image and Optical Property Reconstruction From Noninvasive Measurements of Turbid Media, in Vitro and in Vivo: A Promising Method for Optical Mammography
… enough to include well behaved heterogeneous tissue models in which a number of macroscopic objects of different size and shape are embedded in a homogeneous background medium. I have employed a fitting of the experimental data to the diffusion model to accurately reconstruct not only the …
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Development and Application of Three-dimensional Impedance Maps Related to Tissue Pathology
Three-dimensional acoustic tissue models are a unique means to study ultrasonic scattering by tissue microstructure. In this work, the previous methods used to create and analyze these models were evaluated and refined. These techniques were then applied to a set of 10 human fibroadenomas, a benign …
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Inverse opal hydrogel scaffolds as lymphoid microenvironments for the study of immune cell migration and immunotherapy
… native immunity might be to engineer lymphoid tissue at disease sites (e.g., tumors). Such neotissues could be formed by attracting or transferring immune cells into a defined microenvironment supportive of their activation. In addition to having therapeutic potential, such artificial lymphoid …
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Computational Stress and Deformation Analysis of Mammary Prosthesis
… testing, while linear and non-linear breast tissue models were assumed based on smooth muscle. These material models were to develop axisymmetric finite element models to determine the stresses in the implant walls under tissue loading. The non-linear material models were used to more …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac electrophysiology computational models. Chapter 2 …
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