Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"tissue material properties"”.
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Assessment of material properties in bone surrounding microdamage
… wear-and-tear or fatigue, leading to impaired tissue material properties and in some instances atypical femoral fractures.</p> <p> In these studies, we assessed the effects of acute fatigue, fatigue induced remodeling, and fatigue microdamage with remodeling suppression using the clinical BP, …
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Experimental and Computational Modelling of Tissue Rheology and Mechanics in Morphogenesis
In this thesis, we report two tissue models designed to investigate how key cellular mechanical parameters interact with tissue material properties and active cell behaviour to drive tissue deformation in the context of biological development. Firstly, an experimental, three-dimensional tissue …
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Addressing Challenges of Volume Controlled Cavity Expansion (VCCE) for In-Vivo Tissue Testing
… technology. In general, as with other soft-tissued organs, there exists a gap in understanding of how biological tissues deform under extreme loading conditions. Understanding these mechanics has applications beyond diagnosing physical bodily injuries as diseased tissues have also been shown …
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MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… progression is influenced by dynamic changes in tissue material properties via processes akin to solid-to-fluid phase transitions (PTs), that enable collective motility, immune activation, and tumor invasion. We recently demonstrated that RAB5A, an endocytic small GTPase, induces tissue …
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The Molecular Basis of Tissue Elasticity and Force Balance During Drosophila Gastrulation
The mechanics of folding any material rely on two things: the physical forces forming the fold and the material properties of the substance being folded. When working in biological tissue such as an early Drosophila embryo, there is no existing way to directly measure morphogenetic forces, and the …
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Fluid Flow Forces Regulate Fibrous Extracellular Matrix Protein Expression and Deposition Via A Rhoa/Rho Kinase Dependent Pathway During Atrioventricular Valve Development
… cushion explants exhibited stronger and stiffer material properties compared to the static controls. Further investigation of the mechanotransduction mechanism was carried out by manipulating the RhoA/Rho kinase pathway. From our experiments, RhoA/Rho kinase pathway was shown to bridge the …