Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"tissue invasion"”.
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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion
… the rate of hydrogel replacement by invading tissue was assessed in the 3D spheroid assay and a subcutaneous implant study in a rat model. The covalent coupling of heparin was found to substantially increase the rate of release of bFGF, VEGF and PlGF-2 over 20 days by 23%, 42% and 19%, …
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Concurrent Infections of TRYPANOSOMA EQUIPERDUM and TRICHINELLA SPIRALIS in Mice
… This decrease is probably due to intestinal tissue invasion. Mice infected with trypanosomes after the 7th day of the <em>Trichinella</em> infection have survival time increases to a significant point and a steady leveling off to Day 21. It is suggested that the antibodies produced against …
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Regulation of Cell Invasion by the Podosome/Invadopod Protein Tks5
… of cells. The podosomes of macrophages enable tissue invasion during immunosurveillance and wound healing. Using model THP1 macrophages, my studies have shown that Tks5 can directly control podosome-associated matrix degradation and invasion through collective changes in adhesion, chemotaxis, …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… play an essential role in preventing bacterial invasion of host tissues and maintaining a symbiotic host-bacterial relationship. Autophagy is emerging as an important component of innate immunity. Mounting evidence suggests that dysregulation of the autophagy-independent function of autophagy …
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Cytopathic Effects of a Pathogenic Naegleria fowleri and an Anti-Nfa1 Antibody on Rat Microglial Cells
… mechanisms of N. fowleri concerned with host tissue invasion, the adherence of amoeba to host cells is most important. The nfa1 gene (360 bp) was previously cloned from a cDNA library of pathogenic N. fowleri by immunoscreening, and produced a 13.1 kDa recombinant protein (rNfa1) that showed …
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Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate
… signaling pathways to inhibit angiogenesis and tissue destruction in RA. However, little research has been done to determine the effect of EGCG in the TNF-mediated pathways in RA synovial fibroblasts. In these experiments, we investigated the effects EGCG has on the TNF-α-induced signal …
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Disease resistance in sucrose polyester coated conference pears inoculated with Penicillium expansum and Monilinia fructigena
… physiology and biochemistry of ‘Conference’ pear tissues; to determine how Semperfresh® affects the rate of tissue invasion by Penicillium expansum and Monilinia fructigena; and to determine the physiological basis for any such effect. ‘Conference’ pears coated with 0.5 or 1% Semperfresh® and …
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The Relationship Between Biofilm Production and Human Respiratory Cell Attachment and Invasion by Acinetobacter Baumannii
… ventilator-associated pneumonia, skin and soft tissue infections, and bloodstream infections that often lead to septicemia. Increasing multidrug resistance (MDR) in <em>A. baumannii</em> warrants new approaches to understanding its virulence mechanisms and pathogenicity. As a first step in …
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… migration and accumulation of T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration and are often involved in cancer progression. Most of these proteins are post-translationally isoprenylated to facilitate their anchorage to membranes, where they …
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Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model
… models have been implemented to study pathogen tissue invasion and resultant damage. These models fail to incorporate an innate immune component such as macrophages, essential for study of host response to infection. Macrophages exist within a regulatory to inflammatory polarisation spectrum, …
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Describing motions in biological tissues: a continuum active model and improving measurements
Motions in biological tissues strongly influence their properties and are crucial for their functions. This is true starting from the scale of single molecules, all the way up to the scale of entire tissues. One of the key properties distinguishing motions in living systems from those in dead …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… leading to an increased inflammatory response to tissue pathogens, as in the case of bovine respiratory disease. This response is consistent with the short-term neutrophilia and leukocyte activation that has been observed in response to multiple stressors such as weaning and transportation in …
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… in degradation of the extracellular matrix and tissue remodeling heavily implicated in tumor migration and survival. We identified two gelatinases, MMP-2 and MMP-9, to be expressed in Rb cell lines and demonstrated by pharmacological inhibition and genetic knockdown, a role for these gelatinases …