Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 100 for “"tissue injury"”.
-
Biomarkers of neurological tissue injury and inflammation in paediatric tuberculous meningitis
… these are lacking. Biomarkers of neurological injury could help to assess severity and to prognosticate, but have not been assessed in paediatric TBM. This study examined serum and cerebrospinal fluid (CSF) biomarkers of neurological injury in paediatric TBM in association with clinical and …
-
Defining the Relationship Between Mechanical Stress and Inadvertent Intestinal Tissue Injury In Laparoscopic Surgery
… an inappropriate amount of force when handling tissue is much higher in laparoscopic surgery than in open surgical approaches because surgeons lose the ability to directly touch and feel delicate tissue. The two most commonly injured tissues in laparoscopic surgery are the small bowel (55.8%) …
-
Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
… methodology, we describe several novel types of tissue injury in the rat dentate gyrus following pump failure, which can be summarized as follows: (1) Pump inhibition results in an increase in membrane porosity that occurs as early as the 1-hour time point. Furthermore, pump inhibition enhances …
-
EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
… progressive cognitive dysfunction caused by injury to irradiated normal brain tissue. The cellular and molecular mechanisms underlying radiation-induced normal brain tissue injury have not been fully elucidated. Neuroinflammation, in the form of microglial activation, and decreased …
-
Role of non-enhanced CT characteristics for differentiating reversible and irreversible brain tissue injury and estimating the tissue fate in acute ischaemic stroke
… used to distinguish between areas of salvageable tissue at risk (Penumbra), and irreversibly damaged tissue (infarct core) in patients with ischaemic stroke. It also seeks to predict the outcome of brain tissue fate - whether it will develop into infarct or show signs of recovery - within 24-48 …
-
Identifying Image Derived Features of Radiation Therapy Response: Tumor and Normal Tissue
… tumors and detection of radiation-induced normal tissue injury. Using preclinical models, quantitative image features will be mined from MR and PET scans in radioresponsive and radioresistant tumors to establish universal and tumor-specific imaging markers of treatment response. Furthermore we …
-
Amelioration of oxidative lung injury by antiarrhythmic agents
… antioxidant properties. Ischemia-reperfusion injury has been studied in many organs. Despite the evidence of functional, metabolic and structural abnormalities during reperfusion, the precise mechanism of reperfusion lung injury remains obscure. Data from the organ models suggest that toxic …
-
Host modulation of excessive innate immune responses
… response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that contribute to the elimination of the microbe are the same …
-
Therapeutic Application of Carbon Monoxide in Acute Limb Compartment Syndrome
… within a surgical window of 6-8 hours, before tissue damage becomes permanent. Carbon monoxide (CO), a byproduct of heme metabolism, has been shown protective in ischemia. While inhalation of CO leads to elevation of carboxyhemoglobin (COHb), recent development of transitional metal carbonyls, …
-
Comparison of Cone-Beam Computed Tomography (CBCT), Fan-Beam Computed Tomography (FBCT), and Low-Field Magnetic Resonance Imaging (MRI) for Detection of Equine Fetlock Lesions
… of CT and MRI for detection of bone and soft tissue lesions is essential for the most efficient application in equine practices. The aim of the work presented in this thesis was to compare cone-beam CT (CBCT), 64-slice fan-beam CT (FBCT), and low-field (0.27 Tesla) MRI for detection of equine …
-
Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… the moment we are born we become susceptible to injury and infection and must, therefore, have mechanisms in place to rapidly and effectively repair damaged tissues. The goal of this dissertation work was two-fold. First, this work sought to gain insights into the mediators of …
-
Utilization of Musculoskeletal Sonography in Detecting Physiologic Changes of the Median Nerve in a Working Animal Model
… increase in nerve dysfunction is associated with tissue injury, resulting from repetitive movements of the median nerve through the carpal tunnel. At this point of diagnosis inflammation or ischemic processes may have already begun compromising nerve function, both locally, and systemically. In …
-
RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO
… brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year. Recent reports indicate that radiation-induced brain injury is …
-
PROTECTION OF ISCHEMIA REPERFUSION INJURY IN MURINE LIVER BY GENE SILENCING OF COMPLEMENT 3
It has been documented that ischemia reperfusion injury (IRI) in the liver is associated with complement pathway activation. Thus, blocking complement 3 (C3) genes using a small hairpin RNA (shRNA) can potentially prevent liver IRI. Gene silencing of C3 in vivo was achieved via the administration …
-
The inflammatory response to acute maximal sprint exercise
… seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in …
-
Design and Synthesis of Hyaluronan:RHAMM Interaction Inhibitors
… and differentiation during response-to-injury processes. The receptor for hyaluronan-mediated motility (RHAMM) binds to HA and has limited constitutive expression but is upregulated during tissue injury. Blocking HA fragment:RHAMM interactions has therapeutic potential for treating …
-
An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… immune system attacks itself, which can lead to tissue injury and organ failure. In this dissertation, different aspects of lupus were studied to better understand the disease. CX3CR1, a surface protein that guides cell migration, was found to influence the production of inflammatory proteins …
-
Metabolic Coordination of Stem Cell Fate Controls Tumor Initiation and Tissue Repair
<p>Tissue stem cells balance fate decisions of self-renewal and differentiation to maintain homeostasis over the lifetime of an organism, as well as to repair tissues upon injury and wounding. Disrupting the balance between self-renewal and differentiation results in pathology: excessive …
-
Flexible, stretchable, and transient electronics for integration with the human body
… with the potential to significantly lower tissue injury and irritation after implants. The development of such soft, biocompatible platforms and integrating them into a biotissue-interfaced system requires suitable choice of materials and engineered structures. Specific directions include …
-
The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… cardiac function and contractility and produce tissue injury. We hypothesized that decreases in cardiac function and contractility, and cellular injury during endotoxemia are due to increased levels of OFRs because of increased production and/or decreased destruction and that the agents which …
Page 1 of 5