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Showing 1 to 14 of 14 for “"tissue inhibitors of metalloproteinases"”.
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The Examination of Leptin Receptors, Matrix Metalloproteinases-2 and -9 and Tissue Inhibitors of Metalloproteinases in the Rat Cervix
… structural changes to accommodate the passage of the newborn at parturition. These physiological changes involve hormonal influences that regulate enzymes involved in collagenolysis and degradation of the extracellular components of the cervix. One hormone that has recently become of interest …
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Lipoteichoic acid from Staphylococcus aureus induced expression of MMP-9 in human middle ear epithelial cells
Change in matrix metalloproteinases (MMPs) and regulation of their tissue inhibitors of metalloproteinases (TIMPs) could play certain role in the pathogenesis of otitis media. This study was designed to evaluate the modulation of MMPs and TIMPs in middle ear epithelium by lipoteichoic acid (LTA) …
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important differences between TIMP family members in their ability to inhibit angiogenic …
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Der Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung chronischer Wunden
The balance between matrix metalloproteinases (MMP´s) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMP´s), play a central role in the process of physiological wound healing. In the present study levels of MMP-2, -8 and -9, as well as TIMP-1 and -2 were measured in fluids of …
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Unraveling the mechanism of ADAMTS13 resistance to protease inhibition
… ADAMTS13 exhibits a prolonged half-life of several days as an active protease, suggesting that it is protected from inhibitors of metalloproteases in blood. Here, we investigate the mechanism by which ADAMTS13 is resistant to protease inhibition. Methods: C-terminal domain truncations of …
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MMP's, TIMP's, PIIINP und Hyaluronan im Serum und Gewebe von Patientinnen mit Kapselfibrose nach alloplastischer Mammaaugmentation
Matrix metalloproteinases (MMPs) and their inhibitors, tissue-inhibitors of metalloproteinases, TIMPs, are in a physiological balance and part of the engineering of the extracellular matrix. Is this system disturbed an imbalance results and therefore fibrotic processes concerning liver fibrosis and …
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
An appropriate transcriptional profile in the placenta and fetal membranes is a necessary requirement for the successful completion of pregnancy since any aberrant variations may lead to the inappropriate timing of birth. Epigenetic regulation through reversible modification of chromatin has …
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Enzymimmunologische und immunhistochemische Untersuchungen zum Einfluss von Matrix-Metalloproteinasen und ihrer Inhibitoren auf die Entstehung der Dupuytren'schen Kontraktur
… disorder characterized by progressive deposition of mature collagen fibers. In other fibrotic diseases affecting organs such as the heart, lung, liver, and skin, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important …
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
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Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex
<p>The relationship of the extra-cellular matrix (ECM) and secreted proteins to intra-cellular functions has an important impact on disease progression. The tissue inhibitors of metalloproteinases (TIMPs), of which there are four, are known for their broad metalloprotease inhibitory abilities. …
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The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.
… oral mucositis is defined as damage of oral mucosa caused by unwanted detrimental effects of the cytotoxic chemotherapy. Oral mucositis presents as widespread painful ulcerations and erythematous eruptions and occurs in between 40-100% of all patients undergoing chemotherapy. …
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Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
Inhibitoren von Matrixmetalloproteinasen (TIMP) können das Wachstum von Zellen direkt beeinflussen und stellen somit wichtige Elemente des "extracellular signaling network" dar. p27Kip1 gehört zur Familie der cyclin-abhängigen Proteinkinase-Inhibitoren und bewirkt einen Stopp des Zellzyklus in der …