Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"tissue growth"”.
-
ADIPOSE TISSUE GROWTH AND MAINTENANCE
… Characterized by an increase in adipose tissue to the point where it is associated with adverse health effects, the prevalence of obesity has nearly tripled over the past fifty years. Though for many years adipose tissue was considered to be merely a storage depot for fatty acids, it is …
-
Connective Tissue Growth Factor in Pancreatitis
… and death. Chronic pancreatitis (CP) involves tissue destruction, exocrine and endocrine insufficiency, increased risk of pancreatic cancer and an extensive fibrotic pathology which is due to unrelenting collagen deposition by pancreatic stellate cells (PSC). Improved understanding of the …
-
CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
Connective tissue growth factor (CTGF, CCN2) is expressed by mesenchymal cells during development. Mice genetically deficient in CCN2 display severe bone defects and die immediately after birth. The molecular basis of this defect is not known. We've used in vitro models of chondrogenesis to show …
-
Mechanisms of growth hormone inhibition of adipose tissue growth
Growth hormone (GH) is a poly-peptide hormone produced by the anterior pituitary. Growth hormone not only stimulates body and muscle growth but also inhibits adipose tissue growth. The overall objective of this study was to determine the mechanisms by which GH inhibits adipose tissue growth. Three …
-
Estrogenic and Antiestrogenic Regulation of Cell Proliferation and Tissue Growth
… the dissimilar effects of E2 and AE on uterine growth. Both E2 and AE stimulated ODC activity. AE were antagonistic to E2 in that pretreatment with either CI628 or U23,469 prevented the second estradiol stimulated peak in ODC activity. Polyamine concentrations on a per cell basis were similarily …
-
big bang, a novel regulator of tissue growth in Drosophila melanogaster
… life in the face of challenges such as rapid growth. Unraveling the mechanisms that regulate tissue growth in epithelial tissues, in order to generate organs of correct size and proportion, remains a crucial goal of developmental biology. A suitable epithelial tissue for studying tissue growth …
-
Evidence for the autocrine/paracrine regulation of tissue growth by the insulin-like growth factors
Many tissues can undergo tissue specific (local) growth in response to various stimuli. The objectives of this thesis were to investigate the local growth of skeletal muscle and brown adipose tissue and the possible involvement of the insulin-like growth factors (IGF-I and IGF-II) in regulating …
-
Characterization of estrogen and glucocorticoid receptors, skeletal muscle protein turnover and tissue growth in lambs treated with trenbolone acetate and estradiol
… receptor, skeletal muscle protein turnover and tissue growth. Twenty-four lambs were utilized. Trenbolone acetate did not ,affect (P>.10) degradation rates in the semitendinosus (ST) and triceps brachii (TB) muscles, the production of cortisol, adrenal weights and cytosolic glucocorticoid …
-
Mathematical Models of Prevascular Tumor Growth by Diffusion
… the early, prevascular stages of solid tumor growth by diffusion under various simplifying assumptions is presented. The advantage of these models is that their degree of complexity is relatively low, which ensures fairly straightforward comparisons with experimental or clinical data (as it …
-
Biochemical investigations on cellular proliferation
… (and their derivatives) and the processes of tissue growth (including wound healing).
-
Mechanical Signals for Compensatory Lung Growth Assessed by High Resolution Computed Tomography
… force and its distribution in regenerative growth in dogs i.e. to quantify lobar lung volumes and density gradients in normal and post-pneumonectomy (following lung resection) lungs. HRCT was used to quantitatively assess regional distribution of lung volume and density gradients among lobes …
-
Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster
Fat is a large cadherin that plays a role in both tissue growth and planar cell polarity (PCP). How Fat regulates these cellular processes is not fully understood. A yeast two-hybrid screen previously identified proteins that can bind the cytoplasmic domain of Fat. Using genome-wide RNAi libraries …
-
Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
Tissue growth, pattern formation and cell metabolism are fundamental to animal development. Coordination of these aspects requires elegant signal transduction systems. In Drosophila, fat (ft) encodes an enormous atypical cadherin that is important for such coordination. Ft functions at the cell …
-
Injectable hyaluronic acid scaffolds for cartilage tissue engineering
… supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide symptomatic relief, the results vary greatly among individuals, and newly formed tissue often does not duplicate the structure, composition or …
-
Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
… to compensatory resumption of olfactory bulb tissue growth. Our findings present strong evidence for exceptional growth plasticity in the rat olfactory system, lasting beyond the normal development period. This plasticity may be mediated, in part, by regulatory and compensatory changes in the …
-
Regional Differences in Brain Structure Underlying Childhood Stuttering Persistence and Recovery: An MRI Study
… the latter often exhibited intermediate tissue volume compared to the other two groups in the regions noted above. Results point to a structural basis for stuttering that is likely associated with inefficient function of cortical, subcortical, and cerebellar structures that normally work …
-
Morphogenetic signaling in growing tissues
… and sizes. The proper size and patterning of tissues are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a graded concentration profile. Upon binding of the morphogens to receptors on the …
-
Modeling cell proliferation in a perfusion tissue engineering bioreactor
… we develop a comprehensive model to simulate a tissue engineering experiment. The experiment takes place in a bioreactor in which a cell seeded porous scaffold is placed, and the scaffold experiences a perfused flow of a nutrient-rich culture medium. The goal of the model is to assist …
-
EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… associated with a 32.8% decrease in connective tissue growth factor (CTGF), a 43.1% inhibition in phosphorylated Smad 2 and a 66.2% reduction in phosphorylated ERK1/2 in the arteriole wall of the cremaster muscle. Microvascular remodeling was independent of TGF-beta expression. The …
-
The Role of Cell Division Orientation during Zebrafish Early Development
… is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual contribution of stereotypical cell division …
Page 1 of 4