Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"tissue factor"”.
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Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants
… procedure. There is growing evidence that the tissue factor-tissue factor pathway inhibitor (TF-TFPI) interaction, a major regulator of haemostasis, plays an important role in the healing response of arteries following PTA. In this study, 1) we reassessed claudicants awaiting femoropopliteal …
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Funktion und Aktivierungsmechanismus eines schnell aktivierbaren Tissue Factor-Systems
Tissue Factor ist der physiologische Initiator der Blutgerinnung. Die Lokalisierung des Tissue Factors in der Gefäßwand verhindert in einem intakten Gefäß den Gerinnungsstart. In der vorliegenden Arbeit beobachteten wir, daß nach einer 5-minütigen Stimulation mit Kollagen Tissue Factor auf der …
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Polyphosphate and tissue factor/factor VIIA as initiators of coagulation
… of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent manner. Nearly all studies of GLA domain-containing coagulation factors, and coagulation in general, have utilized supraphyisologic …
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The tissue factor-factor VII(a) complex in blood coagulation
… the coagulation cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream …
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Plättchenassoziierter Tissue Factor als schnell aktivierbarer, intravaskulärer Starter des menschlichen Gerinnungssystems
Der Tissue Factor (TF) der Gefäßwand gilt heute als der wichtigste Starter der menschlichen Blutgerinnung. Es wird davon ausgegangen, dass die Lokalisation von TF innerhalb der Gefäßwand unter physiologischen Verhältnissen eine strikte Trennung von den plasmatischen Gerinnungsfaktoren …
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Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Cardiac hypertrophy was achieved by aortic …
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A study of the regulation of oestrogen receptor alpha by tissue factor in breast cancer cells
Increased expression of tissue factor (TF) has been associated with invasive forms of breast cancer. In contrast, the expression of oestrogen receptor alpha (ERa) in breast cancer cells is associated with well differentiated breast tumours, with a low invasive potential. The aim of this study was …
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Effect of resection of localised pancreatic cancer on tissue-factor promoted pathways of thrombosis, cell invasion and angiogenesis
… of TE in PC has been reported as high as 57%. Tissue factor (TF) bearing microparticles (MP) have recently been shown to promote thrombosis. The biological link between cancer haemostasis, cell invasion and angiogenesis remains unclear. These three indices may be driven by PC cells directly, be …
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Apoptotic cells promote circulating tumor cell survival and metastasis
… the activity of the coagulation initiator Tissue factor, thereby triggering the formation of platelet clots that protect proximal CTCs. Inhibiting the ability of apoptotic cells to induce coagulation by knocking out Tissue factor, blocking phosphatidylserine, or administering the …
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Development and experimental validation of a novel arterial thrombosis-on-a-chip microfluidic device
… that triggers thrombosis with a collagen and tissue factor spot. These two substrates are exposed in vivo when an atherosclerotic plaque ruptures, and thus represent appropriate biological stimuli to trigger occlusive clot formation within an in vitro model. To allow the ‘time to occlude’ of …
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NMR investigations of blood coagulation: Conformational changes of membrane bilayers and proteins in blood coagulation
… of the soluble, extracellular domain of tissue factor (absent the membrane binding transmembrane helix) are assigned in solution and nanocrystalline samples by solution and solid-state NMR respectively. The chemical shifts are then used to investigate changes in the extracellular domain …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… of human thrombin (HVF18, GKY25) or human tissue factor pathway inhibitor 2 (EDC34), to modulate innate immune responses caused by bacteria or lipopolysaccharide (LPS), were investigated. Thrombin-derived peptides significantly blocked LPS-induced responses including tissue-factor driven …
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Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
… coagulation is known to exist, where coagulation factor VII (FVII) and tissue factor (TF) are considered to be pivotal players. In this thesis the crosstalk between inflammation and coagulation in acute pancreatitis (AP) has been investigated. The results from the first paper, where active site …
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Role of Monocytes and Neutrophils in Thrombosis
… the monocytes to rapidly expose on their surface tissue factor, a potent activator of the blood coagulation cascade. Previously reported to take hours, it was instead found that this process could occur on a timescale as short as five minutes, which, if active, might lead to rapid thrombus growth. …
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Peripheral Leukocytes and Intracerebral Hemorrhage
… recognized to express significant amounts of tissue factor, interact with platelets, and modulate inflammation as well as thrombosis and hemostasis. We conducted the first human study to explore absolute monocyte counts in relation to ICH. We found that baseline peripheral monocyte count was …
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Clotting analysis of blood samples from intensive care unit patients.
… These included coagulation screens, individual factor assays and global assays [calibrated automated thrombography, whole blood and plasma low- dose tissue factor activated rotational thromboelastometry and the clot formation and lysis assay]. Results: Clot initiation in both whole blood and …
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On the induction of inflammatory reactions by Streptococcus pyogenes
… is a surface-bound streptococcal virulence factor with antiphagocytic properties. M proteins can be released from the bacterial surface, and in the present thesis we report that soluble M1 protein is a potent activator of monocytes and T cells. M1 protein-induced monocyte activation involves …
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… polyethylene and uncoated MylarTM. In the bulk, tissue factor (TF) expression (monocytes: ELP1 = 38.6 ± 16.3 %, ELP4 = 33.9 ± 18.1 %) and platelet-leukocyte aggregates determined by CD61 (monocytes: ELP1 = 63.1 ± 17.1 %, ELP4 = 61.8 ± 16.8 %; granulocytes: ELP1 = 62.7 ± 17.0 %, ELP4 = 60.5 ± 20.1 …
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Computational Modeling And Simulation Of Thrombus Formation
… to obstruction of blood vessels, resulting in tissue ischemia or death. This study is aimed to understand the cell-biology and biophysics, at the molecular level, of thrombosis in a blood vessel. We first review the biology underlying thrombosis and the previous mathematical models of thrombus …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… the intrinsic pathway in recombinant coagulation factor VIIa (rFVIIa) therapeutic efficacy. We then extended this mechanistic investigation of rFVIIa to flow assays where clotting is initiated by collagen and immobilized lipidated tissue factor to evaluate the role of the intrinsic tenase in …
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