Global ETD Search
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Showing 1 to 20 of 76 for “"tissue distribution"”.
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Human glutathione S-transferases : characterization, tissue distribution and kinetic studies
… time-dependent inactivation of the enzyme. The tissue distribution and localization of the 3 classes of human GSH S-T in normal and tumour tissue was examined. Antibodies to representatives of the 3 classes were raised in rabbits, and radial immunodiffusion employed to quantitate their …
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Betaine-Homocysteine Methyltransferase: Tissue Distribution, Nutrient Regulation, Genomic Organization, and Promoter Isolation
The electrophoretic mobility (45 kDa) and the nucleotide sequence of the human kidney BHMT has been shown to be identical to liver BHMT. Initial rate data was plotted according to the method of Hanes and the Michaelis Constants were estimated to be 2160 muM and <10 muM for betaine and …
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Comparison of Potential Salmonella Portals of Entry and Tissue Distribution Following Challenge of Poultry
… challenge, which was also recovered from lung tissue. IT administration was more effective or at least as effective at colonizing the ceca of 7d chickens, suggesting that the respiratory tract may be an overlooked potential portal of entry for Salmonellae. Finally, the hypothesis was evaluated …
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Tissue Distribution of a Peptide Transporter mRNA in Sheep, Dairy Cows, Pigs, and Chickens
… was radiolabeled for use as a probe to study the distribution of the mRNA in various tissues. Total RNA was extracted and mRNA was isolated from the epithelium of gastrointestinal segments and other tissues as indicated. Northern blot analysis was conducted using the radiolabeled probe. In sheep …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… in reducing HIV-1 viral loads in plasma, several tissue compartments i.e., the brain and male genital tract have been identified as viral reservoirs which can harbor actively replicating HIV-1 virus (Chan, 2005;Dahl, et al., 2010;Smith, et al., 2007;Solas, et al., 2003). In addition to harboring …
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Identification of Tissue Distribution and Regulation of Bovine Stearoyl-Coa Desaturase by Hormones and Nutrients
Studies were conducted to investigate the tissue distribution of stearoyl-CoA desaturase-1 (SCD) and the regulation of SCD1 protein expression by dietary fat, insulin, polyunsaturated fatty acids (PUFA), and linoleic acid (cis-9, cis-12 18:2). The first study examined tissue distribution of SCD1 …
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Age related changes and tissue distribution of parvalbumin in both normal and dystrophic 129 ReJ mice.
… (TPI) was used to study the concentration and tissue distribution of this protein in both normal and dystrophic male mice at various ages. Western blotting assays were used to screen extracts of hindlimb, forelimb, brain, heart, lung, liver and kidney in 60 day old normal and dystrophic male …
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Tissue Distribution of Administered Zinc-65 and Possible Effect of Dietary Zinc on Vitamin a Metabolism
Made available in DSpace on 2014-12-09T14:29:04Z (GMT). No. of bitstreams: 1 6915265.pdf: 3283607 bytes, checksum: 5c3952a42832386361aa4e3c4077ebea (MD5) Previous issue date: 1969
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HPLC analysis of Romet-30 in chinook salmon (Oncorhynchus tshawytscha): wash-out time, tissue distribution in muscle and liver tissues, and metabolism of sulfadimethoxine
… As antimicrobial residues in edible fish tissues after drug administration is of utmost concern to the consumer's health, analytical assay is required to monitor the antimicrobial residue levels in edible fish tissue. The focus of this research was to identify a "marker" tissue which would …
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The pharmacokinetics of sodium monofluoroacetate (1080) in rabbits
… carried out to investigate the persistence and tissue distribution of 1080 in rabbits and assess the risks associated with secondary poisoning. In this experiment New Zealand Large White rabbits were orally administered 0.1 mg 1080/kg W, a sublethal dose. This study demonstrated that 1080 is …
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Nuclear Hormone Receptor-Mediated Changes of Cholesterol, Triglyceride, and Bile Acid Physiology in Response to Alterations in Cholesterol Absorption and Bile Acid Pool Size in Mice
… in bile acid production. Lastly, I studied the tissue distribution and nuclear hormone receptor-mediated regulation of a class of enzymes called carboxylesterases. This family of enzymes, which participate in neutral lipid hydrolysis, often came up on microarray analysis of metabolic studies, …
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I.~fluorine-18 Labeled Corticosteroids and Progestins for Receptor-Based Imaging of the Brain and of Breast Tumors. II.~Synthesis and NMR Spectrum of (carbon-13(18))-Meso-Hexestrol
… presence of steroid receptors in certain target tissues and tumors provides an avenue for monitoring pathological changes through the use of positron emission tomography and an appropriate fluorine-18 labeled ligand. We have prepared fluorinated analogs of six natural and synthetic …
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Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
… fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios being 43 and 17 at one hour after injection for 1 and 2, respectively. The …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… enhanced by SMEDDS. Moreover, abundant tissue distribution of TMF was also confirmed. As ATE displayed both dose- and time-dependent pharmacokinetics, caution is needed in the medicinal applications of ATE and/or the herbs contain ATE. The results obtain from this PhD study will …
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I. A Structure-Based Approach Toward the Development of a Ligand-Receptor System With Unique Specificity. II. Synthesis and Evaluation of Hexahydrochrysene and Tetrahydrobenzofluorene Derivatives as Selective Estrogen Receptor Modulators
… estrogenic effects. Partial agonists, with a tissue selective agonist/antagonist profile, termed selective estrogen receptor modulators (SERMs), are better candidates for applications in the treatment of estrogen sensitive breast cancer and pathologies associated with postmenopausal …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… affinity; these results were reflected in the tissue distribution studies of the radiolabeled compounds with moderate selective uptake in target tissues (uterus, ovaries) and substantial receptor-mediated uptake in secondary tissues (thymus, muscle, kidney, fat).
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Assessing Body Composition Among Male Collegiate Runners and Swimmers Using Dual-Energy X-ray Absorptiometry (DXA)
… differences in bone mineral density and soft tissue amounts (fat mass versus lean mass) among collegiate runners and swimmers using dual energy X-ray absorptiometry (DXA) for body composition measurement. A data subset was gathered for post-hoc analysis on a group of Caucasian male Cal Poly …
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nerd: A Neuron-Specific Gene in Drosophila Melanogaster Related to Vertebrate GAP-43
… activities and nervous system-specific tissue distribution we argue that nerd represents a functional homolog of vertebrate GAP-43. The possibility of a mutational analysis of nerd makes the study of this gene in Drosophila a valuable extention of previous studies in vertebrate systems. …
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"The Synthesis and Biological Evaluation of Integrated and Conjugated Re/tc-99m-Containing ""3+1"" and Cyclopentadienyltricarbonyl (Cptm) Estrogen Complexes as Receptor-Based Imaging Agents for Breast Cancer"
… both were more polar to some extent. However, tissue distribution studies of the Tc analogs showed no significant change from the original amide 67b, although uptake in many non-target organs was lower."
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Evaluation of the pre-ruminant calf as a model for the study of beta-carotene metabolism in the human
… to that reported from a study of human infants. Tissue distribution of a recently-absorbed dose of $\beta$-carotene also compared well to reports from human tissues, with adrenal and liver tissues containing the highest concentrations. Concentrations in kidney, lung, spleen and adipose tissues …
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